上海交通大学学报（医学版）

上海交通大学学报（医学版）

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秀丽隐杆线虫中与衰老相关的DAF-2/IGF-1信号通路研究进展

毛玉琴，韩三峰，王立顺   

  1. 上海交通大学 医学院附属瑞金医院分子医学中心， 上海 200025
  • 出版日期:2014-06-28 发布日期:2014-06-30
  • 通讯作者: 王立顺, 电子信箱: jywangls@shsmu.edu.cn。
  • 作者简介:毛玉琴（1992—）， 女， 硕士生; 电子信箱: myq110813@163.com。

Advances of DAF-2/IGF-1 signaling pathway relevant to aging in Caenorhabditis elegans

MAO Yu-qin, HAN San-feng, WANG Li-shun   

  1. Center for Molecular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2014-06-28 Published:2014-06-30

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摘要：

衰老是诸多疾病发生的关键因素之一。目前，生物学界关于衰老遗传学的大部分知识和信息都来自于对秀丽隐杆线虫的研究。秀丽隐杆线虫在抗衰老研究中发挥着先锋和主力的作用。DAF-2/IGF-1信号通路是第一个为人类所认识的衰老基因调控机制。该文综述了秀丽隐杆线虫作为模式生物在DAF-2/IGF-1信号通路研究进程中的引领和推动作用，为抗衰老研究提供可借鉴的科研思路和方法。

关键词: 秀丽隐杆线虫, 衰老, DAF-2, IGF-1

Abstract:

Ageing is one of the key factors that cause many diseases. Up-to-date, most knowledge and information about the genetics of ageing in biology comes from the studies on Caenorhabditis elegans (C.elegans). The C.elegans plays an important role in the study of anti-ageing. The first aging regulation mechanism understood by the people is the DAF-2/IGF-1 signal pathway. This paper reviews the leading and promoting effects of C.elegans, which acts as a model organism, on the course of research of the DAF-2/IGF-1 signal pathways and provides helpful ideas and methods for anti-ageing studies.

Key words: Caenorhabditis elegans, ageing, DAF-2, IGF-1