上海交通大学学报(医学版)

• 综述 • 上一篇    下一篇

纳米载药系统在心肌缺血治疗中的应用

薛晓梅, 曹惠敏, 尤纱纱, 何斌   

  1. 上海交通大学 医学院附属新华医院麻醉与重症医学科, 上海 200092
  • 出版日期:2016-09-28 发布日期:2016-10-31
  • 通讯作者: 何斌, 电子信箱: hebinicu@139.com。
  • 作者简介: 薛晓梅(1990—), 女, 硕士生; 电子信箱: xiangrikui0109@163.com。
  • 基金资助:

     国家自然科学基金(81470390,81270003);上海市教育委员会高峰高原学科建设计划(20152218);上海交通大学医工交叉项目(YG2013MS20);新华医院院基金临床研究项目(15LC07)

Application of nano drug delivery system to treatment of myocardial ischemia

XUE Xiao-mei, CAO Hui-min, YOU Sha-sha, HE Bin   

  1. Department of Anesthesiology and SICU, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2016-09-28 Published:2016-10-31
  • Supported by:

    National Natural Science Foundation of China, 81470390, 81270003;Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152218; Shanghai Jiao Tong University Medical Engineering Cross Project, YG2013MS20; Funding for Clinical Trial of Xinhua Hospital, 15LC07

摘要:

冠状动脉粥样硬化导致的心肌缺血是心血管疾病的主要死因。目前,药物治疗仍然是心肌缺血治疗的重要手段。近年来的研究表明,纳米载药系统的应用可增强药物治疗的安全性和有效性,具有很高的临床应用价值。纳米载药系统可通过直接心脏注射和静脉注射2种方式进入体内,在体内通过“被动靶向”或“主动靶向”作用将治疗药物输送至缺血心肌部位,增加药物在缺血部位的富集,从而提高药物疗效。该文对近年来应用于心肌缺血治疗的纳米载药系统作一综述。

关键词: 纳米载药系统, 心肌缺血, 被动靶向, 主动靶向, 临床应用

Abstract:

Myocardial ischemia caused by coronary artery atherosclerosis is the major cause of cardiovascular disease death. Currently, administration of drugs is still an important strategy for myocardial ischemia therapy. Recent studies showed that nano drug delivery system can enhance the safety and efficacy of therapeutic agents and has great value in clinical application. Nano-DDS can deliver drugs via direct heart injection or intravenous injection. The “passive targeting” and “active targeting” properties of the nano-DDS facilitate the delivery of drugs to the site of ischemic myocardium, enhancing the concentration of drugs in the ischemic area, and improving the efficacy. This review summarizes recent studies on the application of nano-DDS to the treatment of myocardial ischemia.

Key words: nano-drug delivery system; myocardial ischemia; passive targeting; active targeting, clinical application