上海交通大学学报（医学版）

上海交通大学学报（医学版）

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胆管细胞癌动物模型的研究进展

沙朦，夏强   

  1. 上海交通大学医学院附属仁济医院肝脏外科，上海 200127
  • 出版日期:2017-03-28 发布日期:2017-03-30
  • 通讯作者: 夏强，电子信箱：xiaqiang@medmail.com.cn。
  • 作者简介:沙朦（1992—），男，博士生；电子信箱：simonsha23@163.com。
  • 基金资助:

    国家自然科学基金（81472243）

Research progress in animal models of cholangiocarcinoma

SHA Meng, XIA Qiang   

  1. Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2017-03-28 Published:2017-03-30
  • Supported by:

    National Natural Science Foundation of China, 81472243

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摘要：

胆管细胞癌（CCA）是一种起源于胆管上皮细胞的恶性肿瘤，其发病率仅次于肝细胞癌，位列肝脏恶性肿瘤第2位。CCA患者预后不良，大部分患者在明确诊断后的几个月内死亡。CCA的发生与多种危险因素相关，包括原发性硬化性胆管炎、肝硬化、化学物质接触和肝吸虫感染等。建立合适的动物模型有助于了解CCA的发生和发展机制，并为开发新型治疗方法奠定基础。常见的CCA动物模型包括致癌物诱发模型、种植瘤模型、手术模型以及转基因模型。

关键词: 胆管细胞癌, 动物模型, 致癌物诱发模型, 转基因模型, 综述文献

Abstract:

Cholangiocarcinoma (CCA) is a malignant neoplasm derived from cholangiocytes. The incidence of CCA is only lower than that of hepatocellular carcinoma and ranked the second in liver malignant cancers. The prognosis of CCA patients is poor and most patients will die within a few months after diagnosis. CCA is related to various risk factors, including primary sclerosing cholangitis, cirrhosis, certain chemical agents and liver fluke. Establishment of proper animal models of CCA can not only be helpful for understanding the mechanisms of incidence and development, but also lay a solid foundation for developing novel treatment strategies. Common animal models of CCA include carcinogen-induced models, implantation models, operation models, and genetically engineered models.

Key words: cholangiocarcinoma, animal models, carcinogen-induced models, genetically engineered models, review