上海交通大学学报（医学版）

上海交通大学学报（医学版）

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肝纤维化与干细胞疗法

徐栋生 1，万爱妮 1，陈蕴 1，何杨 2，杨建峰 3，金坚 1   

  1. 1．江南大学药学院药物设计及药理实验室，无锡 214122；2. 苏州大学第一附属医院江苏血液学研究所，苏州 215006；3. 苏州大学血液病学中心和教育工程中心，苏州 215123
  • 出版日期:2017-03-28 发布日期:2017-03-30
  • 通讯作者: 金坚，电子信箱：jinjian31@163.com。
  • 作者简介:徐栋生（1984—），男，博士生；电子信箱：xudongsheng1122@163.com。
  • 基金资助:

    国家高技术研究发展计划（863计划）（2014AA021003）

Liver fibrosis and stem cell therapy

XU Dong-sheng1, WAN Ai-ni1, CHEN Yun1, HE Yang2, YANG Jian-feng3, JIN Jian1   

  1. 1. Laboratory of Drug Design and Molecular Pharmacology, School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China; 2. Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China; 3. Cyrus Tang Hematology Center and Ministry of Education Engineering Center of Hematological Disease, Soochow University, Suzhou 215123, China

  • Online:2017-03-28 Published:2017-03-30
  • Supported by:

    National High-tech R&D Program of China, 863 Program, 2014AA021003

PDF (PC)

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摘要：

肝纤维化是常见的慢性进行性肝病，是肝脏细胞在一种或多种病因长期或反复作用下进行应激反应的过程。肝纤维化过程中，胞外基质大量累积形成瘢痕组织，引起肝脏功能减退或衰竭，严重危害生命健康。多个独立的研究证明，干细胞治疗促进肝纤维化恢复。干细胞治疗过程中，干细胞迁移至肝损伤部位，通过旁分泌途径改善纤维化瘢痕区域的微环境，延缓纤维化进程。该文从肝纤维化形成过程、肝纤维化治疗和干细胞疗法三方面进行综述。

关键词: 肝纤维化, 干细胞, 肝细胞生长因子, 旁分泌

Abstract:

Liver fibrosis is a common chronic liver disease, which is a stress response process of liver cells affected by one or more pathogenies for long term or repeatedly. During the fibrosis process, massive accumulated extracellular matrix can form scar tissue, which results in liver dysfunction or failure and seriously endangers the health of people. According to many independent reports, stem cell therapy can facilitate the alleviation of liver fibrosis. During the stem cell therapy, stem cells migrate to the injury site of liver and alleviate the liver fibrosis by improving the microenvironment of the scar area via paracrine way. This article reviews the formation, treatment, and stem cell therapy of liver fibrosis.

Key words: liver fibrosis, stem cell, hepatocyte growth factor, paracrine