内源性大麻素系统在肝脏病中作用的研究进展

doi:10.3969/j.issn.1674-8115.2024.10.012

上海交通大学学报（医学版） ›› 2024, Vol. 44 ›› Issue (10): 1299-1306.doi: 10.3969/j.issn.1674-8115.2024.10.012

• 综述 • 上一篇

内源性大麻素系统在肝脏病中作用的研究进展

边姝¹(), 于倩¹, 刘亮明¹^,²()

^1.南京医科大学上海松江临床医学院感染科，上海 201600
^2.上海交通大学医学院附属松江医院感染科，上海 201600

收稿日期:2024-04-22 接受日期:2024-06-04 出版日期:2024-10-28 发布日期:2024-10-28
通讯作者: 刘亮明 E-mail:stacybian@163.com;liuliangming@shsmu.edu.cn
作者简介:边　姝（1998—），女，硕士生；电子信箱：stacybian@163.com。
基金资助:
国家自然科学基金(81770612);上海市松江区科委科技攻关(2023SJKJGG027)

Research progress in the role of endo cannabinoid system in liver diseases

BIAN Shu¹(), YU Qian¹, LIU Liangming¹^,²()

^1.Department of Infection, Shanghai Songjiang Clinical Medical College of Nanjing Medical University, Shanghai 201600, China
^2.Department of Infection, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China

Received:2024-04-22 Accepted:2024-06-04 Online:2024-10-28 Published:2024-10-28
Contact: LIU Liangming E-mail:stacybian@163.com;liuliangming@shsmu.edu.cn
Supported by:
National Natural Science Foundation of China(81770612);Science and Technology Research of Songjiang District Science and Technology Commission in Shanghai(2023SJKJGG027)

摘要/Abstract

摘要：

内源性大麻素系统（endocannabinoid system，ECS）是由多种长链不饱和脂肪酸类似物如花生四酰乙醇酰胺（anandamide，AEA）和2-花生四酰甘油（2-arachidonoyl glycerol，2-AG）及其特异性结合G蛋白偶联受体大麻素受体1（cannabinoid receptor 1，CB1R）和大麻素受体2（cannabinoid receptor 2，CB2R）等组成。通过对细胞物质与能量代谢等方面的影响，ECS几乎影响了机体所有细胞的生命进程和生物学活性。在肝脏，生理性ECS仅低水平表达，肝损伤因素的作用，会强烈刺激肝内ECS的表达和分泌。ECS是多种肝脏疾病共同的参与者。已知，ECS参与了肝细胞脂肪变性过程，促进了非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）和酒精性肝病（alcoholic liver disease，ALD）的形成和发展；参与了肝脏疾病的炎症损伤过程，对肝组织的免疫炎症损伤反应有重要影响；参与了肝纤维形成，促进了肝纤维化和肝硬化的发生与发展。文章通过例举脂代谢相关性肝病（NAFLD和ALD）和其他肝脏病，进一步深入阐述了ECS在肝脏疾病发生发展中的作用及机制。

关键词: 内源性大麻素系统, 非酒精性脂肪性肝病, 酒精性肝病, 肝损伤, 肝纤维化

Abstract:

The endocannabinoid system (ECS) consists of a variety of long-chain unsaturated fatty acid analogs, mainly anandamide (AEA) and 2-arachidoniyl glycerol (2-AG), along with their specific binding G protein-coupled receptors, cannabinoid receptor 1 (CB1R) and cannabinoid receptor 2 (CB2R). It affects the life process and biological activity of almost all cells in the body by influencing cell material and energy metabolism. In the liver, the physiological expression of ECS is at a low level. The expression and secretion of ECS in the liver can be strongly stimulated by liver injury factors. ECS acts as a trigger in multiple liver diseases. It is known to be related to the process of hepatocyte steatosis and promote the formation and development of non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). It is involved in the inflammatory processes of liver diseases and greatly affects the immune-inflammatory response in liver tissue. It is also involved in the formation of liver fibers and promotes the occurrence and development of liver fibrosis and cirrhosis. Finally, the role and mechanisms of ECS in the occurrence and development of liver diseases are elaborated in detail by listing lipid metabolism-related liver diseases (NAFLD and ALD) and other liver diseases.

Key words: endocannabinoid system (ECS), non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), liver injury, hepatic fibrosis

中图分类号:

R575.5

边姝, 于倩, 刘亮明. 内源性大麻素系统在肝脏病中作用的研究进展[J]. 上海交通大学学报（医学版）, 2024, 44(10): 1299-1306.

BIAN Shu, YU Qian, LIU Liangming. Research progress in the role of endo cannabinoid system in liver diseases[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(10): 1299-1306.

图/表 2

参考文献 48

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内源性大麻素系统在肝脏病中作用的研究进展

Research progress in the role of endo cannabinoid system in liver diseases

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