全氟化合物对性激素干扰作用的研究进展

doi:10.3969/j.issn.1674-8115.2021.04.021

摘要/Abstract

摘要：

全氟化合物（perfluorinated compounds，PFCs）是一类在环境和生物体内广泛存在的持久性有机污染物，已有研究表明其与肝脏毒性、免疫毒性、神经毒性等有关。近年来，越来越多的研究提示PFCs具有内分泌干扰效应，其生殖毒性备受关注，尤其是其对性激素合成分泌的影响。当性激素水平紊乱时，机体可能出现性分化发育异常、生殖障碍等表现。该文从动物毒理学研究及其机制、人群流行病学研究的角度，对PFCs与性激素水平的关系进行阐述，并对今后研究的方向进行讨论和展望。

关键词: 全氟化合物, 持久性有机污染物, 性激素

Abstract:

Perfluorinated compounds (PFCs) are a class of persistent organic pollutants that are widely distributed in the environment and biota. Studies have shown that PFCs have liver-toxicity, immune-toxicity and neuro-toxicity, etc. In recent years, due to an increasing number of studies suggesting that PFCs have endocrine disrupting effects, their reproductive toxicity has attracted much attention, especially their interference with the synthesis and secretion of sex hormone which may induce abnormalities in sexual differentiation and development, reproductive disorders, etc.This article reviews the relationship of PFCs with sex hormone levels and the potential mechanisms from animal toxicology experiments and epidemiological studies, thus providing the theoretical basis for PFCs research in the future.

Key words: perfluorinated compound, persistent organic pollutant, sex hormone

中图分类号:

R122.7

汪子夏, 姚谦, 田英. 全氟化合物对性激素干扰作用的研究进展[J]. 上海交通大学学报(医学版), 2021, 41(4): 540-545.

Zi-xia WANG, Qian YAO, Ying TIAN. Advance in research of interference effect of perfluorinated compounds on sexhormones[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(4): 540-545.

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