围产期母体心理健康对子代心血管系统的影响综述

doi:10.3969/j.issn.1674-8115.2026.03.016

摘要/Abstract

摘要：

围产期母体心理健康问题如抑郁、焦虑、压力等，是影响子代长期健康的重要风险因素。尽管部分流行病学证据和动物实验支持两者之间存在关联，但由于现实世界中存在遗传、社会环境、生活方式等多重混杂因素，并且多数观察性研究在因果推断上存在局限，两者之间的确切因果关系仍存在一定争议。该文总结相关流行病学调查、基础及临床研究进展，探讨围产期母体抑郁、焦虑等不良心理健康状态对子代心血管系统结构与功能的近期和远期影响，及其潜在的生物学机制；提出未来需要进一步整合前瞻性队列设计、表观遗传学及代谢组学等多组学研究，并结合干预性实验，系统阐明其内在的生物学路径与因果机制，从而为制定有效的预防和干预策略提供依据。

关键词: 围产期心理健康, 心血管结局, 跨代健康, 母婴健康管理

Abstract:

Perinatal maternal mental health problems, such as depression, anxiety, and stress, are important risk factors affecting the long-term health of offspring. Although some epidemiological evidence and animal studies support an association between maternal mental health and offspring cardiovascular outcomes, the exact causal relationship remains controversial due to the presence of multiple confounding factors, such as genetic predisposition, social environment, and lifestyle, as well as the inherent limitations of causal inference in most observational studies. This article summarizes current advances in epidemiological, clinical, and basic research, and explores the short-long-term effects of maternal depression, anxiety, and other adverse mental health conditions during the perinatal period on the structure and function of the offspring cardiovascular system, as well as their potential biological mechanisms. The article further suggests that future research should further integrate prospective cohort designs with multi-omics approaches, including epigenomics and metabolomics, and combine these with interventional studies to systematically elucidate the underlying biological pathways and causal mechanisms, thereby providing a solid basis for the development of effective prevention and intervention strategies.

Key words: perinatal mental health, cardiovascular outcomes, intergenerational health, maternal-infant healthcare management

中图分类号:

R715.3

徐雨林, 杜博文, 王鉴, 孙锟. 围产期母体心理健康对子代心血管系统的影响综述[J]. 上海交通大学学报（医学版）, 2026, 46(3): 408-414.

Xu Yulin, Du Bowen, Wang Jian, Sun Kun. Review of impact of maternal perinatal mental health on offspring cardiovascular system[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(3): 408-414.

图/表 1

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