纹唇后异物肉芽肿：病例系列报道及文献回顾

doi:10.3969/j.issn.1674-8115.2026.10.016

上海交通大学学报（医学版） ›› 2026, Vol. 46 ›› Issue (10): 1449-1454.doi: 10.3969/j.issn.1674-8115.2026.10.016

• 病例报告 • 上一篇

纹唇后异物肉芽肿：病例系列报道及文献回顾

王臻元¹, 邵如如¹, 唐国瑶², 杜观环¹()

^1.上海交通大学医学院附属第九人民医院口腔黏膜病科，上海交通大学口腔医学院，国家口腔医学中心，口腔疾病国家临床医学研究中心，上海市口腔医学重点实验室，上海市口腔医学研究所，上海 200011
^2.上海交通大学医学院附属新华医院口腔科，国家口腔疾病临床医学研究中心核心单位，上海 200092

收稿日期:2026-03-25 接受日期:2026-05-20 出版日期:2026-10-28 发布日期:2026-10-28
通讯作者: 杜观环，副主任医师，博士；电子信箱：dgh-09@163.com。
基金资助:
上海市卫生健康委员会2025年度中医重点病种建设项目(ZDBZ-202623)

Foreign body granulomas after lip tattooing: a case series and literature review

Wang Zhenyuan¹, Shao Ruru¹, Tang Guoyao², Du Guanhuan¹()

^1.Department of Oral Mucosal Diseases, Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai 200011, China
^2.Department of Stomatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Core Unit of National Clinical Research Center for Oral Diseases, Shanghai 200092, China

Received:2026-03-25 Accepted:2026-05-20 Online:2026-10-28 Published:2026-10-28
Contact: Du Guanhuan, E-mail: dgh-09@163.com.
Supported by:
2025 Key Disease Construction Project of Traditional Chinese Medicine of Shanghai Municipal Health Commission(ZDBZ-202623)

摘要/Abstract

摘要：

纹唇后异物肉芽肿（foreign body granuloma）是纹唇材料进入机体组织引起的慢性炎症性反应，其组织病理学表现为肉芽肿性炎症。该文报告3例纹唇术后出现的异物肉芽肿伴慢性唇炎的患者，并结合既往文献对其治疗、预后等内容进行讨论，以期提高诊疗水平，改善患者的生活质量。

关键词: 异物肉芽肿, 纹唇, 糖皮质激素, 唇炎

Abstract:

Foreign body granuloma after lip tattooing is a chronic inflammatory response caused by the introduction of tattooing materials into the tissues, and its histopathological manifestation is granulomatous inflammation. This article reports three cases of foreign body granulomas accompanied by chronic cheilitis following lip tattooing, and discusses their treatment and prognosis in light of the existing literature, aiming to improve diagnosis and treatment and enhance patients' quality of life.

Key words: foreign body granuloma, lip tattooing, corticosteroids, cheilitis

中图分类号:

R781.5

王臻元, 邵如如, 唐国瑶, 杜观环. 纹唇后异物肉芽肿：病例系列报道及文献回顾[J]. 上海交通大学学报（医学版）, 2026, 46(10): 1449-1454.

Wang Zhenyuan, Shao Ruru, Tang Guoyao, Du Guanhuan. Foreign body granulomas after lip tattooing: a case series and literature review[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026,(10): 1449-1454.

图/表 4

参考文献 22

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[2]	Chatterjee D, Bhattacharjee R, Saikia U N. Non-infectious granulomatous dermatoses: a pathologist's perspective[J]. Indian Dermatol Online J, 2021, 12(4): 515-528.
[3]	Nakamizo S, Kabashima K. Cutaneous granulomas: mechanisms, cellular interactions and therapeutic insights[J]. Br J Dermatol, 2025, 192(6): 974-982.
[4]	Klontz K C, Lambert L A, Jewell R E, et al. Adverse effects of cosmetic tattooing: an illustrative case of granulomatous dermatitis following the application of permanent makeup[J]. Arch Dermatol, 2005, 141(7): 918-919.
[5]	Martín J M, Revert Á, Monteagudo C, et al. Granulomatous reactions to permanent cosmetic tattoos successfully treated with topical steroids and allopurinol[J]. J Cosmet Dermatol, 2007, 6(4): 229-231.
[6]	Jones B, Oh C, Egan C A. Spontaneous resolution of a delayed granulomatous reaction to cosmetic tattoo[J]. Int J Dermatol, 2008, 47(1): 59-60.
[7]	Kamouna B, Litov I, Bardarov E, et al. Granuloma formation after oil-soluble vitamin D injection for lip augmentation-case report[J]. J Eur Acad Dermatol Venereol, 2016, 30(8): 1435-1436.
[8]	Jin Y T, Yu-Fong Chang J, Lang M J, et al. Cosmetic materials-induced foreign body granuloma at the lower lip[J]. J Dent Sci, 2022, 17(1): 586-588.
[9]	Gao X Y, Xiang W Z. Reflectance confocal microscopy as a tool for the diagnosis of labial foreign body granuloma caused by red tattoo pigment: a case report[J]. Skin Res Technol, 2023, 29(1): e13261.
[10]	Wu Y H, Lee Y P, Sun A, et al. Polymethylmethacrylate-induced foreign body granuloma in the left lower lip[J]. J Dent Sci, 2025, 20(2): 1303-1305.
[11]	do Carmo Silva R, Mühleisen B, Vasconcelos-Berg R, et al. Methotrexate and triamcinolone as a nonsurgical management for polymethyl methacrylate-induced granulomatous reaction: a case report[J]. JAAD Case Rep, 2026, 70: 7-10.
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[14]	Scofield-Kaplan S M, Patel S Y, Mueller A, et al. Foreign-body granulomata caused by injected permanent filler masquerading as cutaneous sarcoidosis[J]. Ophthalmic Plast Reconstr Surg, 2019, 35(3): e82-e84.
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Author	Sex/Age	Medical history	Clinical feature	Histological feature	Treatment
Klontz et al.^[4]	F/32	Lip tattooing 5 months earlier; lip lesion developed shortly after the procedure	Indurated, erythematous papules	Epidermal hyperplasia, papillary dermal edema, and granuloma formation	Topical corticosteroids + imiquimod cream + laser therapy
Martín et al.^[5]	F/59	Lip tattooing 6 years earlier, with lip lesions developed 2 years ago	An erythematous nodule measuring 1×0.8 cm on the left side of the upper vermilion	Non-caseating granulomas composed of epithelioid cells and Langhans cells, with brownish-black pigment	Topical corticosteroids + oral allopurinol
Jones et al.^[6]	F/27	Lip tattooing 4 years earlier; papules developed 4 months ago	Discrete, elongated, yellowish papules, some of which coalesced linearly along the upper and lower vermilion borders	Dense dermal histiocytic granulomatous inflammation with abundant granular pigmentation	Resolved spontaneously without treatment
Kamouna et al.^[7]	F/30	A lip lesion developed 2 years after Vitamin D injection for lip augmentation	2 firm dermal nodules located on the left side of the upper lip and the lower lip	Fibrotic collagen and foreign body granulomas containing multinucleated giant cells	Surgery
Jin et al.^[8]	F/61	A lesion on the left lower lip for more than 2 months	A tender, elastic, palpable subcutaneous nodule on the left lower lip	Granulomatous fibrous micronodules with epithelioid macrophages, multinucleated giant cells, and lymphocytes	Surgery
Gao et al.^[9]	F/43	Hyperplasia of the upper and lower lip mucosa for 4 months; history of lip tattooing	Irregular hyperplasia of the upper and lower lip mucosa confined to the vermilion, with mild localized edema	Numerous macrophages in the papillary dermis containing red tattoo pigment granules in the cytoplasm	Topical tacrolimus ointment
Wu et al.^[10]	F/43	A lip lesion developed 2 years after the injection of dermal filler	A nontender, firm mass on the left lower labial mucosa	Numerous round vacuoles surrounded by epithelioid cells, a few multinucleated giant cells, and mild lymphocytic infiltration	Surgery
do Carmo Silva et al.^[11]	F/40	Lip swelling for 3 days, with a history of lip filler injection 1 year earlier	Nodules, erythema, and edema in the perioral region	A deep foreign body granulomatous reaction with characteristic PMMA microspheres	Oral methotrexate + triamcinolone injection

Author	Sex/Age	Medical history	Clinical feature	Histological feature	Treatment
Klontz et al.^[4]	F/32	Lip tattooing 5 months earlier; lip lesion developed shortly after the procedure	Indurated, erythematous papules	Epidermal hyperplasia, papillary dermal edema, and granuloma formation	Topical corticosteroids + imiquimod cream + laser therapy
Martín et al.^[5]	F/59	Lip tattooing 6 years earlier, with lip lesions developed 2 years ago	An erythematous nodule measuring 1×0.8 cm on the left side of the upper vermilion	Non-caseating granulomas composed of epithelioid cells and Langhans cells, with brownish-black pigment	Topical corticosteroids + oral allopurinol
Jones et al.^[6]	F/27	Lip tattooing 4 years earlier; papules developed 4 months ago	Discrete, elongated, yellowish papules, some of which coalesced linearly along the upper and lower vermilion borders	Dense dermal histiocytic granulomatous inflammation with abundant granular pigmentation	Resolved spontaneously without treatment
Kamouna et al.^[7]	F/30	A lip lesion developed 2 years after Vitamin D injection for lip augmentation	2 firm dermal nodules located on the left side of the upper lip and the lower lip	Fibrotic collagen and foreign body granulomas containing multinucleated giant cells	Surgery
Jin et al.^[8]	F/61	A lesion on the left lower lip for more than 2 months	A tender, elastic, palpable subcutaneous nodule on the left lower lip	Granulomatous fibrous micronodules with epithelioid macrophages, multinucleated giant cells, and lymphocytes	Surgery
Gao et al.^[9]	F/43	Hyperplasia of the upper and lower lip mucosa for 4 months; history of lip tattooing	Irregular hyperplasia of the upper and lower lip mucosa confined to the vermilion, with mild localized edema	Numerous macrophages in the papillary dermis containing red tattoo pigment granules in the cytoplasm	Topical tacrolimus ointment
Wu et al.^[10]	F/43	A lip lesion developed 2 years after the injection of dermal filler	A nontender, firm mass on the left lower labial mucosa	Numerous round vacuoles surrounded by epithelioid cells, a few multinucleated giant cells, and mild lymphocytic infiltration	Surgery
do Carmo Silva et al.^[11]	F/40	Lip swelling for 3 days, with a history of lip filler injection 1 year earlier	Nodules, erythema, and edema in the perioral region	A deep foreign body granulomatous reaction with characteristic PMMA microspheres	Oral methotrexate + triamcinolone injection

纹唇后异物肉芽肿：病例系列报道及文献回顾

Foreign body granulomas after lip tattooing: a case series and literature review

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