上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (11): 1550-.doi: 10.3969/j.issn.1674-8115.2011.11.010

• 专题报道（双相障碍） • 上一篇    下一篇

双相障碍早期识别的研究进展

黄 佳, 苑成梅, 方贻儒   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科, 上海 200030
  • 出版日期:2011-11-28 发布日期:2011-11-29
  • 通讯作者: 方贻儒, 电子信箱: yirufang@yahoo.com.cn。
  • 作者简介:黄 佳（1983—）, 女, 住院医师, 硕士；电子信箱: kittyhj_2000@yahoo.cn。
  • 基金资助:

    国家自然科学基金（30971047）；国家高技术研究发展计划（“八六三”计划）(2006AA02Z430)；上海交通大学医学院“重点学科建设”基金（沪交医科[2008]-6）；“十五”国家科技攻关计划（2004BA720A21-02）；上海市科委“登山行动计划”（064119533, 2006-2008）；上海市卫生局公共卫生优秀青年人才项目（08GWQ075）；上海市卫生局青年科研项目（2007Y14）

Research progress of early diagnosis of bipolar disorder

HUANG Jia, YUAN Cheng-mei, FANG Yi-ru   

  1. Division of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    National Natural Science Foundation of China, 30971047；National High Technology Research and Development Program of China, “863” Program, 2006AA02Z430；Shanghai Jiaotong University School of Medicine Foundation, 2008-6；National Key Technology Research and Development Program of China in “Tenth-Five Year Plan”, 2004BA720A21-02；Shanghai Science and Technology Committee Foundation, 064119533, 2006-2008；Shanghai Municipal Health Bureau Foundation, 08GWQ075, 2007Y14

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摘要：

双相障碍是一种严重的精神疾病。大多数双相障碍以抑郁发作起病，易被误诊为单相抑郁症而延误治疗，影响预后，因此早期识别双相障碍十分重要。双相障碍发病机制复杂，涉及多个不同的领域，目前针对其特征性分子生物学指标的研究较少。该文针对双相障碍的遗传学、神经内分泌功能及神经信息传递的生化机制等领域的相关研究进展进行综述，探讨对双相障碍具有早期诊断意义的分子生物学指标。

关键词: 双相障碍, 单相抑郁症, 早期识别

Abstract:

Bipolar disorder is a kind of serious mental disease. Bipolar disorder occurs as depression in most cases, which may result in the misdiagnosis as unipolar depression, delayed therapy and unfavorable prognosis. Therefore, the early diagnosis of bipolar disorder is very important. The pathogenesis of bipolar depression is extremely complicated, which concerns with numerous fields. However, few studies have focused on the specific molecular biomarkers in bipolar depression. This review is to introduce the research progress of early diagnosis of bipolar disorder on the fields of genetics, neuroendocrine and biochemistry, discussing the molecular biomarkers which may contribute to the early diagnosis of bipolar disorder.

Key words: bipolar disorder, unipolar depression, early diagnosis