上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (11): 1440-.doi: 10.3969/j.issn.1674-8115.2012.11.010

• 专题报道（病原微生物学） • 上一篇    下一篇

细菌泛基因组学的研究

庄绪冉, 朱泳璋   

  1. 上海交通大学 基础医学院病原生物学教研室, 上海 200025
  • 出版日期:2012-11-28 发布日期:2012-11-30
  • 作者简介:庄绪冉 (1987—), 女, 硕士生；电子信箱: xuran.bao@163.com。
  • 基金资助:

    国家自然科学基金（81171587）

Research progress of bacterial pan-genome

ZHUANG Xu-ran, ZHU Yong-zhang   

  1. Department of Medical Microbiology and Parasitology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2012-11-28 Published:2012-11-30
  • Supported by:

    National Natural Science Foundation of China, 81171587

PDF (PC)

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摘要：

细菌是自然界中最古老的生物种群之一，不同菌种之间甚至是同一种菌的不同株系之间也具有丰富的遗传多样性，在表型特征上具有明显分化，这些分化的遗传基础主要源自菌株之间的基因组遗传信息的差异。为了更全面地在基因组水平上揭示细菌种内个体间的遗传多样性，进一步探寻个体间的系统发生关系和个体间表型差异的遗传基础，科学家提出了细菌泛基因组学的概念，该文对细菌菌种遗传多样性的形成机制、泛基因组的研究策略及其在细菌研究中的应用和进展等作一综述。

关键词: 泛基因组, 多菌株测序, 遗传多样性, 核心基因组, 附属基因组

Abstract:

Bacterium, one of the most ancient organisms, has great diversity and obvious differentiation in phenotype among different strains and even in different lines of one strain. The hereditary basis of differentiation is due to the genomic genetic information difference among different strains. In order to illustrate the individual genetic diversity and explore the hereditary basis of individual phylogenesis and phenotype difference, the concept of pan-genome is put forward. The causes of hereditary diversity of bacteria, the research strategy of pan-genome and its application in bacterial research are reviewed in this paper.

Key words: pan-genome, multiple strain sequencing, genetic diversity, core genome, accessory genome