›› 2012, Vol. 32 ›› Issue (4): 508-.doi: 10.3969/j.issn.1674-8115.2012.04.029

• 论著(预防医学) • 上一篇    下一篇

我国四川、广西、新疆地区女性性工作者对暴露前预防用药预防HIV感染接受意愿调查

邱 蕾1, 田考聪1, 钟晓妮1, 张 燕1, 彭 斌1, 梁 浩2, 邹云锋3, 罗锦昆4, 彭鸿斌4, 黄爱龙5   

  1. 1.重庆医科大学公共卫生学院卫生统计学教研室, 重庆 400016; 2.广西医科大学公共卫生学院流行病与卫生统计学教研室, 南宁 530021; 3.广西医科大学公共卫生学院毒理学教研室, 南宁 530021; 4.四川省南充市顺庆区疾病预防控制中心, 南充 637000; 5.重庆医科大学感染性疾病分子生物学教育部重点实验室, 重庆 400016
  • 出版日期:2012-04-28 发布日期:2012-04-27
  • 通讯作者: 田考聪, 电子信箱: tkc5155@126.com;钟晓妮, 电子信箱: zxn66@vip.sina.com。
  • 作者简介:邱 蕾(1988—), 女, 硕士生;电子信箱: qiulei2010@sina.com。
  • 基金资助:

    国家科技重大专项项目(2008ZX10001-016)

Investigation on acceptability of pre-exposure prophylaxis among female sex workers in Sichuan, Xinjiang and Guangxi of China

QIU Lei1, TIAN Kao-cong1, ZHONG Xiao-ni1, ZHANG Yan1, PENG Bin1, LIANG Hao2, ZOU Yun-feng3, LUO Jin-kun4, PENG Hong-bin4, HUANG Ai-long5   

  1. 1. Department of Medical Statistics, School of Public Health, Chongqing Medical University, Chongqing 400016, China;2.Department of Epidemiology and Medical Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China;3.Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China;4.Sichuan Nanchong Shunqing District Center of Disease Control and Prevention, Nanchong 637000, China;5.Key Laboratory of Molecular Biology for Infectious Diseases of Ministry of Education, Chongqing Medical University, Chongqing 400016, China
  • Online:2012-04-28 Published:2012-04-27
  • Supported by:

    National Major Science and Technology Program, 2008ZX10001-016

摘要:

目的 了解我国四川省、新疆维吾尔自治区、广西壮族自治区女性性工作者(FSWs)对暴露前预防用药(Pr-EP)预防人类免疫缺陷病毒(HIV)感染的接受意愿及其影响因素。方法 采用问卷调查的形式,调查对象为四川省、新疆维吾尔自治区、广西壮族自治区的FSWs。调查完成问卷1 478份,有效问卷1 469份(占99.39%)。调查内容主要为FSWs对Pr-EP的知晓情况和接受意愿。结果 经调查人员介绍了Pr-EP相关知识后,在Pr-EP安全有效的前提下,共有801人(54.5%)表示“肯定愿意使用”,有196人(13.3%)表示“可能会使用”,Pr-EP使用意愿为67.9%(997/1469),三个地区间的差异无统计学意义(P>0.05)。经过单因素χ2检验和Logistic回归分析,结果显示:Pr-EP的接受意愿的影响因素包括危险自评(OR=1.776,P=0.005)、性服务安全套使用(OR=1.346,P=0.000)、最近三次发生性交易使用安全套的频率(OR=1.519,P=0.003)、是否使用过药物预防性病(OR=1.185,P=0.025)、是否拒绝与不使用安全套的人发生性行为(OR=1.479,P=0.009)、是否会建议朋友接受Pr-EP(OR=5.618,P=0.000)。三个地区FSWs对Pr-EP比较关注的是其安全性/不良反应、效果/有效性、费用。结论 坚持使用安全套的FSWs更倾向于接受Pr-EP;应该加大Pr-EP相关知识的宣传力度,提高FSWs对Pr-EP知晓率,进一步提高FSWs对于Pr-EP的接受意愿;同伴教育可能是推广Pr-EP的有效方式。

关键词: 人类免疫缺陷病毒, 女性性工作者, 暴露前预防用药, 接受意愿

Abstract:

Objective To investigate the acceptability and influencing factors of pre-exposure prophylaxis (Pr-EP) for human immunodeficiency virus (HIV) among female sex workers (FSWs) in Sichuan, Xinjiang and Guangxi of China. Methods FSWs selected from Sichuan, Xinjiang and Guangxi were surveyed with questionnaires. A total of 1 478 questionnaires were completed, among which 1 469 (99.39%) were effective. The survey mainly concerned with the awareness and acceptability of FSWs on Pr-EP. Results After introduction to Pr-EP by the investigators, under the precondition that Pr-EP was effective and safe, 997(67.9%) FSWs accepted Pr-EP, and there was no significant difference in the acceptability among FSWs in three regions (P>0.05). Univariate χ2 analysis and Logistic regression analysis revealed that self-evaluation of risks (OR=1.776, P=0.005), regular condom use in sex service (OR=1.346, P=0.000), frequency of condom use during the latest three times of sex service (OR=1.519, P=0.003), drug use to prevent sexually-transmitted disease (OR=1.185, P=0.025), refusal of having sex with those without condom use (OR=1.479, P=0.009) and advising peers to use Pr-EP (OR=5.618, P=0.000) were influencing factors of acceptability of Pr-EP. FSWs mainly concerned of the security, effectiveness and cost of Pr-EP. Conclusion FSWs with regular condom use are more likely to accept Pr-EP. Pr-EP related knowledge should be well exposed among FSWs to increase the awareness and acceptability. Peer education may be a better way to improve the acceptability of Pr-EP.

Key words: human immunodeficiency virus, female sex worker, pre-exposure prophylaxis, acceptability