上海交通大学学报（医学版）

上海交通大学学报（医学版）

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高通量药物筛选模型的研究进展

许媛媛1，陈鹏辉1，吴英理2   

  1. 上海交通大学 医学院 1.临床医学专业五年制2009级， 2.细胞分化与凋亡教育部重点实验室， 上海 200025
  • 出版日期:2013-10-28 发布日期:2013-10-31
  • 通讯作者: 吴英理, 电子信箱: wuyingli@shsmu.edu.cn。
  • 作者简介:许媛媛（1991—）， 女， 本科生; 电子信箱: dongdong170@sina.com。

Research progress of high throughput drug screening models

XU Yuan-yuan1, CHEN Peng-hui1, WU Ying-li2   

  1. 1.Grade 2009 of 5-year Clinical Medicine Program, 2.Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2013-10-28 Published:2013-10-31

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摘要：

作为高通量筛选系统的核心，筛选模型在研究深入与技术进步的推动下已得到较大发展与广泛应用。文章从分子、细胞和动物水平三个层面介绍高通量药物筛选模型的研究状况及应用，并对其优缺点与相关机制进行阐述。

关键词: 高通量筛选, 药物筛选, 筛选模型

Abstract:

As the core of high throughput screening systems, screening models have enjoyed remarkable development and wider application driven by intensive studies and technology advancement. Discussed in this paper are the latest progress in molecule, cell and animal based models of high throughput screening and their recent applications in drug screening, as well as their pros and cons and related theories.

Key words: high throughput screening, drug screening, models