上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

糖尿病视网膜病变患者血清转化生长因子β水平研究

罗大卫, 郑 志, 刘 堃, 朱弼珺, 夏 欣, 许 迅, 邹海东   

  1. 上海交通大学附属第一人民医院眼科， 上海 200080
  • 出版日期:2013-07-28 发布日期:2013-08-22
  • 通讯作者: 刘 堃, 电子信箱: drliukun@gmail.com。
  • 作者简介:罗大卫（1977—），男，主治医师，硕士; 电子信箱: dr-davie@yeah.net。
  • 基金资助:

    上海市眼底病重点实验室开放课题基金（07Z22911）

Serum transforming growth factor-β levels in patients with diabetic retinopathy

LUO Da-wei, ZHENG Zhi, LIU Kun, ZHU Bi-jun, XIA Xin, XU Xun, ZOU Hai-dong   

  1. Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2013-07-28 Published:2013-08-22
  • Supported by:

    Shanghai Key Laboratory for Ocular Fundus Disease Foundation, 07Z22911

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摘要：

目的 探讨糖尿病视网膜病变患者血清转化生长因子β(TGF-β)水平变化。方法 72例糖尿病患者分为增生性糖尿病视网膜病变组(PDR组，n=15）、非增生性糖尿病视网膜病变组(NPDR组，n=32)和无糖尿病视网膜病变组(NDR组，n=25) ；以45名体检健康者作为正常对照组。采用酶联免疫吸附法测定各组血清TGF-β水平。结果 糖尿病患者TGF-β水平显著高于正常对照组(P<0.01)，PDR组血清TGF-β水平显著高于NPDR组和NDR组（P<0.05）。结论 TGF-β水平与糖尿病视网膜病变的病变程度密切相关。

关键词: 糖尿病视网膜病变, 转化生长因子β, 增生性视网膜病变

Abstract:

Objective To investigate the serum transforming growth factor-β (TGF-β) levels in patients with diabetic retinopathy  (DR). Methods Seventy-two patients with diabetes were selected, including 15 patients with proliferative diabetic retinopathy (PDR group), 32 patients with non-proliferative diabetic retinopathy (NPDR group) and 25 patients with non-diabetic retinopathy group (NDR group). Besides, 45 healthy people were served as normal control group. The serum TGF-β levels were detected by ELISA. Results Serum TGF-β levels in groups with diabetes were significantly higher than that in normal control group (P<0.01). Serum TGF-β level in PDR group was significantly higher than those in NPDR group and NDR group (P<0.05). Conclusion Serum TGF-β level is associated with the severity of diabetic retinopathy.

Key words: diabetic retinopathy, transforming growth factor-β, proliferative diabetic retinopathy