上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 综述 • 上一篇    下一篇

人乳头瘤病毒E6/E7 mRNA与宫颈病变关系的研究进展

张生枝，邵华江，马建婷   

  1. 宁波大学 医学院附属阳明医院妇产科， 余姚 315400
  • 出版日期:2014-05-28 发布日期:2014-05-30
  • 通讯作者: 邵华江, 电子信箱: yyphshj@163.com。
  • 作者简介:张生枝（1987—）， 女， 硕士生; 电子信箱: Jelly888520@126.com。

Advances of relationship between E6/E7 mRNA of human papillomavirus and cervical lesions

ZHANG Sheng-zhi, SHAO Hua-jiang, MA Jian-ting   

  1. Department of Obstetrics & Gynecology, Yangming Hospital affiliated to Medical School of Ningbo University, Yuyao 315400, China
  • Online:2014-05-28 Published:2014-05-30

PDF (PC)

1120

摘要：

人乳头瘤病毒与子宫颈癌的发生和发展密切相关，其中病毒癌基因E6、E7的表达是致癌的关键，当病毒基因整合进入宿主基因后，E6、E7基因过度表达，最终导致子宫颈癌的发生。文章对E6、E7基因转录产物E6/E7 mRNA的研究进展进行综述。

关键词: 人乳头瘤病毒, E6/E7 mRNA, 宫颈病变

Abstract:

Human papillomavirus (HPV) is closely related to the occurrence and development of cervical cancer and the expressions of carcinogenic gene E6 and E7 of the virus are the key to the carcinogenesis. When the virus gene integrates into the host, the E6 and E7 gene will be over-expressed and eventually lead to the occurrence of cervical cancer. This paper reviews the research developments of E6 / E7 mRNA, which is the transcription product of E6 and E7 gene.

Key words: human papillomavirus, E6/E7 mRNA, cervical lesions