上海交通大学学报（医学版）

上海交通大学学报（医学版）

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胰岛素样生长因子Ⅰ信号通路与乳腺癌靶向治疗的研究进展

梁 跃，陈小松，沈坤炜   

  1. 上海交通大学  医学院附属瑞金医院乳腺疾病诊治中心， 上海 200025
  • 出版日期:2014-05-28 发布日期:2014-05-30
  • 作者简介:梁 跃（1989—）， 女， 硕士生; 电子信箱: dr.liangyue@hotmail.com。

Advances of insulin-like growth factor Ⅰ signaling pathway and therapeutic target of breast cancer

LIANG Yue, CHEN Xiao-song, SHEN Kun-wei   

  1. Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2014-05-28 Published:2014-05-30

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摘要：

胰岛素样生长因子Ⅰ信号（IGF-Ⅰ）通路与乳腺癌的治疗效果密切相关。因此，以IGF-Ⅰ为乳腺癌靶向治疗新靶点的相关研究受到越来越多的关注，相关靶向药物也已进入临床前研究或临床试验，显示了良好的基础研究和临床应用前景。该文就IGF-Ⅰ的靶向药物及研究进展作一综述。

关键词: 乳腺癌, 胰岛素样生长因子Ⅰ信号通路, 靶向治疗

Abstract:

The insulin-like growth factor Ⅰ (IGF-Ⅰ) signaling pathway has been found to be closely related to the therapeutic effect of breast cancer. Researches on using the IGF-Ⅰ as a new target for the target therapy of breast cancer have attracted more and more attention. Pre-clinical studies or clinical tests have been conducted for relevant targeted drugs and showed good prospect of basic researches and clinical applications. This paper reviews targeted drugs and research developments of IGF-Ⅰ.

Key words: breast cancer, insulin-like growth factor Ⅰ signaling pathway, target therapy