上海交通大学学报（医学版）

上海交通大学学报（医学版）

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血管紧张素（1-7）/Mas——肺部疾病治疗的新靶点

刘玉静，李颖川   

  1. 上海交通大学附属第六人民医院麻醉科， 上海 200233
  • 出版日期:2015-09-28 发布日期:2015-09-30
  • 通讯作者: 李颖川, 电子信箱: yingchuan.li@sjtu.edu.cn。
  • 作者简介:刘玉静（1991—）， 女， 硕士生; 电子信箱: liuyujing0823@126.com。
  • 基金资助:

    国家自然科学基金（81272145）

Angiotensin-(1-7)/Mas: novel therapeutic targets for treatment of pulmonary diseases

LIU Yu-jing, LI Ying-chuan   

  1. Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2015-09-28 Published:2015-09-30
  • Supported by:

    National Natural Science Foundation of China， 81272145

PDF (PC)

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摘要：

肺组织是血管紧张素转化酶(ACE)表达和血管紧张素Ⅱ(AngⅡ)生成的主要场所。已有研究表明肾素—血管紧张素系统(RAS)参与了急性呼吸窘迫综合征、肺动脉高压、肺纤维化、哮喘及肺癌的发病过程。RAS内存在ACE/AngⅡ/血管紧张素Ⅱ 1型受体(AT1R)和血管紧张素转化酶2(ACE2)/血管紧张素(1-7)[Ang-(1-7)]/Mas两大轴系。AngⅡ通过其特异性受体AT1R参与了多种肺部疾病的发生与进展，而Ang-(1-7)通过作用于其特异性受体Mas发挥对抗AngⅡ的作用。文章对Ang-(1-7)/Mas在几种常见肺部疾病中的保护性作用及其可能的分子机制进行综述。

关键词: 血管紧张素（1-7）, Mas, 血管紧张素Ⅱ, 肺疾病

Abstract:

Lung is a major site for the expression of angiotensin-converting enzyme (ACE) and generation of angiotensin Ⅱ (AngⅡ). Studies have showed that the renin-angiotensin system (RAS) involves in the pathogenesis of acute respiratory distress syndrome, pulmonary fibrosis, pulmonary hypertension, asthma, and lung cancer. There are two axes in the RAS, i.e. the ACE/AngⅡ/angiotensin Ⅱ type 1 receptor (AT1R) axis and the ACE2/angiotensin-(1-7) [Ang-(1-7)]/Mas axis. AngⅡ involves in the incidence and development of many pulmonary diseases through its specific receptor AT1R, while Ang-(1-7) counteracts the effect of AngⅡ via specific receptor Mas. This paper reviews the protective effect and possible molecular mechanisms of Ang-(1-7)/Mas during the course of several common pulmonary diseases.

Key words: angiotensin-(1-7), Mas, angiotensin Ⅱ, pulmonary disease