上海交通大学学报（医学版）

上海交通大学学报（医学版）

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精子鞭毛结构蛋白研究进展

宋平平，邹沙沙,李铮，胡洪亮   

  1. 上海交通大学 医学院附属仁济医院泌尿外科， 上海 200001
  • 出版日期:2015-09-28 发布日期:2015-09-30
  • 作者简介:宋平平（1989—）， 女， 硕士生; 电子信箱: spiong1230@163.com。
  • 基金资助:

    上海交通大学医学院附属仁济医院种子基金（RJZZ14-017）；国家自然科学基金（30973069，30672146）

Research advances of structural proteins of sperm flagella

SONG Ping-ping, ZOU Sha-sha, LI Zheng, HU Hong-liang   

  1. Department of Urology， Renji Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200001， China
  • Online:2015-09-28 Published:2015-09-30
  • Supported by:

    Foundation of Renji Hospital， Shanghai Jiao Tong University School of Medicine， RJZZ14-017； National Natural Science Foundations of China， 30973069， 30672146

PDF (PC)

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摘要：

精子鞭毛是成熟精子的动力器官，其基于微管的轴丝结构在进化过程中高度保守。精子鞭毛结构和功能相关蛋白质的缺陷或缺失，均会导致精子运动功能障碍，进而导致男性不育。该文对精子尾部形成及动力相关分子的最新研究进展进行综述，这类分子结构与功能的障碍与临床许多疾病息息相关。

关键词: 精子, 鞭毛, 动力, 蛋白质

Abstract:

The flagellum is the motility organ of mature sperms and its microtubule based axoneme structure is highly conservative during evolution. The defect or missing of sperm flagella protein, which is relevant to the structure and function of sperms, can lead to motility dysfunction of sperms and cause male infertility. This paper reviews the latest research advances of molecules relevant to the formation and motility of sperm tails. Problems of structure and function of these molecules are closely related to many clinical diseases.

Key words: sperm, flagellum, motility, protein