上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

乳腺非典型性导管增生与乳腺癌的关系

许艳春， 姚晓虹， 许恪淳， 管雯斌， 王立峰， 祝明洁   

  1. 上海交通大学 医学院附属新华医院病理科， 上海 200092
  • 出版日期:2016-10-28 发布日期:2016-11-29
  • 通讯作者: 祝明洁， 电子信箱： m-jzhu@hotmail.com。
  • 作者简介:许艳春（1987—）， 女， 硕士生； 电子信箱： yanchun0538@126.com。

Association between breast atypical ductal hyperplasia and breast cancer

XU Yan-chun， YAO Xiao-hong， XU Ke-chun， GUAN Wen-bin， WANG Li-feng， ZHU Ming-jie   

  1. Department of Pathology， Xinhua Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200092， China
  • Online:2016-10-28 Published:2016-11-29

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摘要：

目的·探讨乳腺非典型性导管增生（ADH）与乳腺癌的关系。方法·收集乳腺癌和非乳腺癌标本共442例，其中浸润性癌253例，非浸润性癌（导管内原位癌）79例（低级别25例，高级别54例），非乳腺癌110例。观察ADH的形态及免疫组织化学染色情况；对各类病变的ADH检出率进行统计学分析。结果·ADH直径均小于2 mm；腺腔细胞CK5/6表达阴性，肌上皮细胞p63表达阳性。非浸润性癌ADH检出率显著高于非乳腺癌和浸润性癌（均P=0.000）;非浸润性癌低级别病变的ADH检出率显著高于浸润性癌和非浸润性癌高级别病变（均P=0.000）。结论·乳腺的ADH病变与导管原位癌的关系密切，及时发现和切除这种病变对预防乳腺癌发生有重要意义。

关键词: 非典型性导管增生, 浸润性乳腺癌; , 导管原位癌;免疫组织化学染色

Abstract:

Objective·To explore the association between breast atypical ductal hyperplasia （ADH） and breast cancer. Methods·A total of 442 benign and malignant breast samples were collected, including 253 invasive carcinoma samples, 79 noninvasive carcinoma (ductal carcinoma in situ, 25 low grade carcinoma and 54 high grade carcinoma) samples, and 110 benign samples. Histological characteristics and immunohistochemical changes of ADH were observed. The detection rates of ADH in different types of samples were statistically analyzed. Results·The diameters of ADH were all less than 2 mm. Lumens cells were negative for CK5/6 and myoepithelial cells were positive for p63. The detection rate of ADH in noninvasive carcinoma samples was significantly higher than those in benign samples and invasive carcinoma samples (both P=0.000). The detection rate of ADH in low grade noninvasive carcinoma was significantly higher than those in invasive carcinoma samples and high grade noninvasive carcinoma (both P=0.000). Conclusion·Breast ADH is closely associated with ductal carcinoma in situ. Timely detection and removal of ADH are important for preventing breast cancer.

Key words: typical ductal hyperplasia, invasive breast cancer, ductal carcinoma in situ, immunohistochemical staining