›› 2013, Vol. 33 ›› Issue (4): 516-.doi: 10.3969/j.issn.1674-8115.2013.04.029

• 综述 • 上一篇    下一篇


许艳春, 姚晓虹, 祝明洁   

  1. 上海交通大学 医学院附属新华医院病理科, 上海 200092
  • 出版日期:2013-04-28 发布日期:2013-05-03
  • 通讯作者: 姚晓虹, 电子信箱: xinhuayiyuan@hotmail.com。
  • 作者简介:许艳春(1987—), 女, 硕士生; 电子信箱: yanchun0538@126.com。

Research progress of breast atypical ductal hyperplasia

XU Yan-chun, YAO Xiao-hong, ZHU Ming-jie   

  1. Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2013-04-28 Published:2013-05-03



关键词: 非典型性导管增生, 分子特点, 遗传学, 细胞外基质


Breast atypical ductal hyperplasia (ADH) has the risk of progression into breast cancer, and there are characteristic molecular biological and genetic changes in ADH, which is to some extent similar to ductal carcinoma in situ (DCIS). The increase of cell proliferation index, hormone receptor expression and cell growth regulating factors may promote the formation of ADH. Chromosome abnormality and epigenetic changes may lead to the formation of ADH, among which 16p, 17q chromosome abnormality and promoter methylation of cancer related gene may be the early events of ADH. Studies have confirmed that ADH is the precursor of low grade ductal carcinoma in situ (LG-DCIS) which shares the similar molecular biological characteristics and genetic performance with ADH, and can progress to low grade invasive ductal carcinoma (LG-IDC) through LG-DCIS stage. Studies have also pointed out that ADH is not the precursor of high grade ductal carcinoma in situ (HG-DCIS), and high grade invasive ductal carcinoma (HG-IDC) has different pathogenesis. With the abnormal expression of cell adhesion molecule, extracellular matrix produces a large number of matrix protease which results in reduced cell-to-cell adhesion and degradation of basement membrane, and ultimately promotes the development of ADH to IDC.

Key words: atypical ductal hyperplasia, molecular features, genetics, extracellular matrix