上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (4): 510-.doi: 10.3969/j.issn.1674-8115.2013.04.028

• 综述 • 上一篇    下一篇

MicroRNA——乳腺癌诊治及预后判断的新方向

杜 威1, 火子榕1, 梁成才1, 陶诗聪1, 孙岳平2   

  1. 上海交通大学 1.医学院临床医学专业八年制2009级； 2.基础医学院生物化学与分子细胞生物学系, 上海 200025
  • 出版日期:2013-04-28 发布日期:2013-05-03
  • 通讯作者: 孙岳平, 电子信箱: jysunyp@shsmu.edu.cn。
  • 作者简介:杜 威（1990—）, 男, 本科生； 电子信箱: duweiwilson@qq.com。

MicroRNA—new approach to diagnosis, treatment and prognosis prediction of breast cancer

DU Wei1, HUO Zi-rong1, LIANG Cheng-cai1, TAO Shi-cong1, SUN Yue-ping2   

  1. 1.Grade 2009 of the 8-year Medical Education Program, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China； 2.Department of Biochemitstry and Molecular Cell Biology, Basic Medical College Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2013-04-28 Published:2013-05-03

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摘要：

MicroRNA （miRNA）是一种非编码的小分子RNA，能在转录后水平调节基因的表达，并在几乎所有的细胞功能活动中发挥作用。研究表明miRNA在乳腺癌的发生、发展中具有重要的作用，成为乳腺癌诊治和预后判断的新希望。该文主要介绍miRNA在乳腺癌研究方面的进展，并对miRNA的应用作简要的分析和展望。

关键词: 乳腺癌, MiRNA, 诊断, 治疗, 预后判断, 个性化医疗

Abstract:

MicroRNA (miRNA) is a small and non-coding RNA that regulates gene expression at the post-transcriptional level, affecting on almost all the cellular processes. Recent studies have revealed the important role of miRNA in the tumorigenesis and development of breast cancer, indicating a new hope for its diagnosis, treatment and prognosis prediction. The latest progress in miRNA studies on breast cancer is introduced in this paper, and the potential application of miRNA is analysed.

Key words: breast cancer, MiRNA, diagnosis, therapy, prognosis predition, personalized therapy