上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (4): 506-.doi: 10.3969/j.issn.1674-8115.2013.04.027

• 综述 • 上一篇    下一篇

JAK/STAT信号通路在动脉粥样硬化中的作用

黄伟彬, 吕 磊, 张 岚   

  1. 上海交通大学 医学院附属仁济医院血管外科, 上海 200127
  • 出版日期:2013-04-28 发布日期:2013-05-03
  • 通讯作者: 张 岚, 电子信箱: lucky200207@yahoo.com.cn。
  • 作者简介:黄伟彬（1987—）, 男, 硕士生； 电子信箱: jiaodahuangwb@163.com。

Effect of JAK/STAT pathway in atherosclerosis

HUANG Wei-bin, Lü|Lei, ZHANG Lan   

  1. Department of Vascular Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2013-04-28 Published:2013-05-03

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摘要：

动脉粥样硬化（AS）是一种慢性炎症疾病，包含血管细胞和炎症细胞之间复杂的相互作用。酪氨酸激酶/信号转导子和转录激活子（JAK/STAT）信号通路是多种细胞因子和生长因子在细胞内传递信号的共同途径，参与机体免疫反应、血管细胞迁移增殖和凋亡等多种生物学活动。文章对目前JAK/STAT信号通路在AS发生和发展中的作用进行了综述。

关键词: 动脉粥样硬化, JAK/STAT信号通路, 内皮细胞, 平滑肌细胞, 炎症细胞

Abstract:

Atherosclerosis is a chronic inflammatory disease including complex interactions between vascular cells and inflammatory cells. Janus kinase/signal transducer and activator of transcription(JAK/STAT) pathway acts as a common intracellular transduction pathway of various of cytokines and growth factors, which involves in many biological activities such as immunological response and growth, migration and apoptosis of vascular cells. The effects of JAK/STAT pathway on the development and progression of atherosclerosis are reviewed in this paper.

Key words: atherosclerosis, JAK/STAT pathway, endothelial cells, smooth muscle cells, inflammatory cells