上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (1): 117-.doi: 10.3969/j.issn.1674-8115.2018.01.022

• 综述 • 上一篇    

Temozolomideresistanceinhighgradegliomas#br#

WEI Xiang-yu, XIE Chao-ran, YOU Chao-guo, CHEN Zheng, ZHENG Xue-sheng   

  1. Department of Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • 出版日期:2018-01-28 发布日期:2018-03-09
  • 通讯作者: ZHENG Xue-sheng（郑学胜），电子信箱：zhengxuesheng@xinhuamed.com.cn。
  • 作者简介:?WEI?Xiang-yu?（卫翔宇）（1993—），男，硕士生；电子信箱：weixiangyu.ok@163.com。
  • 基金资助:
     Scientific Research Project of Science and Technology Committee of Shanghai Municipality, 14DZ1930303。

Temozolomideresistanceinhighgradegliomas#br#

WEI Xiang-yu, XIE Chao-ran, YOU Chao-guo, CHEN Zheng, ZHENG Xue-sheng   

  1. Department of Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2018-01-28 Published:2018-03-09
  • Supported by:
     Scientific Research Project of Science and Technology Committee of Shanghai Municipality, 14DZ1930303。

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摘要： High grade gliomas are always the research focus in the field of neurosurgery due to their poor prognosis despite the current standard therapeutic regimen of surgical resection followed by radiation therapy and chemotherapy. Alkylating agent temozolomide has been established as the  standard chemotherapy while its resistance inevitable during treatment. This phenomenon seriously influences the prognosis of patients suffering from  high grade gliomas. This review aims to elucidate temozolomide chemoresistance mechanisms through three chapters including O6-methylguanine-DNA methyltransferase (MGMT) methylation, mismatch repair mutation and epigenetic regulation consisting of p21, chromatin and histone, Y-box binding  protein-1 and microRNAs.

关键词: &ensp, high&ensp, grade&ensp, glioma, &ensp, temozolomide, &ensp, resistance, &ensp, O6-methylguanine-DNA&ensp, methyltransferase, &ensp, mismatch&ensp, repair

Abstract:

High grade gliomas are always the research focus in the field of neurosurgery due to their poor prognosis despite the current standard therapeutic regimen of surgical resection followed by radiation therapy and chemotherapy. Alkylating agent temozolomide has been established as the  standard chemotherapy while its resistance inevitable during treatment. This phenomenon seriously influences the prognosis of patients suffering from  high grade gliomas. This review aims to elucidate temozolomide chemoresistance mechanisms through three chapters including O6-methylguanine-DNA methyltransferase (MGMT) methylation, mismatch repair mutation and epigenetic regulation consisting of p21, chromatin and histone, Y-box binding  protein-1 and microRNAs.

Key words: high&ensp, grade&ensp, glioma, &ensp, temozolomide, &ensp, resistance, &ensp, O6-methylguanine-DNA&ensp, methyltransferase, &ensp, mismatch&ensp, repair