上海交通大学学报(医学版) ›› 2018, Vol. 38 ›› Issue (1): 52-.doi: 10.3969/j.issn.1674-8115.2018.01.009

• 论著(临床研究) • 上一篇    下一篇

MTA2 在子宫内膜癌中的表达及其与临床病理特征的关系

高灵通,刘玮   

  1. 上海交通大学附属第一人民医院病理中心,上海 200080
  • 出版日期:2018-01-28 发布日期:2018-03-09
  • 通讯作者: 刘 玮,电子信箱:bsjys@shsmu.edu.cn。
  • 作者简介:高灵通(1991—),男,硕士生,电子信箱:lingtonggao@126.com。
  • 基金资助:
    国家自然科学基金(81302253);上海市卫生和计划生育委员会项目(20124y081)

Expression of MTA2 in endometrial carcinomas and its correlation with clinicopathological features

GAO Ling-tong, LIU Wei   

  1. Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
  • Online:2018-01-28 Published:2018-03-09
  • Supported by:
    National Natural Science Foundation of China,81302253;Program of Shanghai Municipal Commission of Health and Family Planning,20124y081

摘要: 目的· 探讨MTA2 在子宫内膜癌中的表达及其与临床病理指标的相关性。方法· 采用GCBI 数据库分析MTA2 在各肿瘤组织中的mRNA 表达水平。采用免疫组织化学染色法检测MTA2、ER、PR、p53 和Ki-67 在119 例子宫内膜癌组织和21 例癌旁组织中的蛋白表达水平,并统计分析MTA2 表达与子宫内膜癌临床病理特征的关系及与ER、PR、p53 和Ki-67 表达的相关性。结果· 在GCBI 数据库中,MTA2 在包括子宫内膜癌在内的多数肿瘤中的表达均上调。MTA2 在子宫内膜癌患者组织中的表达显著高于癌旁组织表达水平(P=0.000);MTA2 的表达与肿瘤分级有关(χ2=8.072,P=0.018);MTA2 在子宫内膜癌中的表达与Ki-67 的表达呈正相关
(r=0.227,P=0.013),而与ER、PR 和p53 的表达无相关性。结论· MTA2 在子宫内膜癌发生和发展的过程具有重要作用,预示MTA2具有成为诊断分子的潜能。

关键词:  , 子宫内膜癌;MTA2;表达;肿瘤分级;Ki-67

Abstract:

Objective · To explore the expression of MTA2 in endometrial carcinomas and its correlation with clinicopathological features.
Methods · The GCBI database was used to analyse the MTA2 expression in most cancers. Immunohistochemical staining of MTA2, p53, ER, PR and Ki-
67 was performed in 119 endometrial carcinomas tissues and 21 corresponding adjacent non-neoplastic endometria. And the correlation between MTA2
expression and clinicopathological characteristics was evaluated as well as the correlation between MTA2 expression and the expression of ER, PR, p53
or Ki-67. Results · The expression of MTA2 was up-regulated in most of the tumors including endometrial carcinomas in GCBI database. MTA2 was
overexpressed in endometrial carcinoma compared with the adjacent normal tissues (P=0.000),and the expression level was related to tumor grade
(χ2=8.072, P=0.018) and Ki-67 expression (r=0.227, P=0.013). Conclusion · MTA2 may act as an oncogene in endometrial carcinomas, and it is a promising target for diagnosis and treatment of endometrial carcinomas.

Key words: endometrial carcinomas, MTA2, expression, tumor grade, Ki-67