上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (12): 1442-.doi: 10.3969/j.issn.1674-8115.2019.12.017

• 论著·临床研究 • 上一篇    下一篇

2型糖尿病患者糖化血红蛋白与血黏度及外周动脉血流的相关性研究

陈 丽，陈颖超，仰礼真   

  1. 上海交通大学医学院附属第九人民医院内分泌代谢科，上海200011
  • 出版日期:2019-12-28 发布日期:2020-02-06
  • 通讯作者: 仰礼真,电子信箱：dryanginsh@sina.com。
  • 作者简介:陈 丽（1993—），女，硕士生；电子信箱：2422157904@qq.com。

Correlation of hemoglobin A1c with blood viscosity and peripheral arterial blood flow in patients with type 2 diabetes mellitus

CHEN Li, CHEN Ying-chao, YANG Li-zhen   

  1. Division of Endocrinology and Metabolism, Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Online:2019-12-28 Published:2020-02-06

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摘要： 目的·探讨2型糖尿病（type 2 diabetes mellitus，T2DM）患者糖化血红蛋白（hemoglobin A1c，HbA1c）与血黏度及外周动脉血流的相关性。方法·345例T2DM患者均获检血糖、HbA1c、血黏度以及外周动脉血管超声，并按HbA1c水平分为4组：A组（HbA1c结果·B、C、D组（HbA1c≥7%）在1/s、5/s、30/s、200/s剪切率下全血黏度均显著高于A组（HbA1cP结论·T2DM患者中血HbA1c水平与血黏度、全血HSRV呈正相关，与左右侧颈内动脉内径呈显著负相关性，但未见与外周动脉血流有明显相关性。

关键词: 糖化血红蛋白, 2型糖尿病, 血黏度, 全血高剪切还原黏度, 外周动脉血管超声

Abstract:

Objective · To investigate the relationship of hemoglobin A1c (HbA1c) with blood viscosity and peripheral arterial blood flow in patients with type 2 diabetes mellitus (T2DM). Methods · A total of 345 patients with T2DM were divided into four groups according to the HbA1c levels: group A (HbA1c≤ HbA1c≤ HbA1c≥ 10.0%, 77 cases). All patients were tested for blood glucose, HbA1c, blood viscosity and peripheral arterial ultrasound. Spearman and Pearson correlation as well as stepwise multivariate regression analyses were performed to analyze the data. Results · The whole blood viscosities at 1/s, 5/s, 30/s and 200/s shear rates of group B, C and D (HbA1c ≥ 7%) were significantly higher than those of group A (HbA1c≥ 8.5%) were significantly higher than those of group A and B (HbA1c(P(PPConclusion · The blood HbA1c levels in T2DM patients are positively correlated with blood viscosity, and HSRV, and negatively correlated with left and right internal carotid arterial inner diameters, but have no significant correlation with peripheral arterial blood flow velocity.

Key words: hemoglobin A1c (HbA1c), type 2 diabetes mellitus, blood viscosity；high shear reduction viscosity of whole blood, peripheral arterial ultrasound