上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (12): 1618-1620.doi: 10.3969/j.issn.1674-8115.2020.12.008

• 论著·临床研究 • 上一篇    下一篇

血清白介素-6水平与精神分裂症伴抑郁症状之间的关系

文万军1，陈 晔1，覃宗厚1，吕望强2，唐 伟3，卢卫红4，范卫星2，张 晨4   

  1. 1. 广东省韶关市粤北第三人民医院精神科，韶关 512200；2. 浙江省金华市第二医院精神科，金华321016；3. 温州医科大学附属康宁医院精神科，温州 325000；4. 上海交通大学医学院附属精神卫生中心精神科，上海 200030
  • 出版日期:2020-12-28 发布日期:2021-02-02
  • 通讯作者: 张 晨，电子信箱：zhangchen645@gmail.com。
  • 作者简介:文万军（1976—），男，副主任医师，学士；电子信箱：wenwanjun@sina.com。
  • 基金资助:
    国家自然科学基金（81771450）。

Relationship between serum interleukin-6 level and depressive symptoms in schizophrenia

WEN Wan-jun1, CHEN Ye1, QIN Zong-hou1, LÜ Wang-qiang2, TANG Wei3, LU Wei-hong4, FAN Wei-xing2, ZHANG Chen4   

  1. 1. Department of Psychiatry, Yuebei Third People’s Hospital, Shaoguan, Guangdong Province, Shaoguan 512200, China; 2. Department of Psychiatry, The Second Hospital of Jinhua, Zhejiang Province, Jinhua 321016, China; 3. Department of Psychiatry, The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou 325000, China; 4. Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-12-28 Published:2021-02-02
  • Supported by:
    National Natural Science Foundation of China (81771450).

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摘要： 目的·探索血清白介素-6（interleukin-6，IL-6）水平与精神分裂症伴抑郁症状之间的关系。方法·招募239例使用奥氮平单药治疗2年以上的精神分裂症患者。采用卡尔加里精神分裂症抑郁量表（Calgary Depression Scale for Schizophrenia，CDSS）评估患者的抑郁水平，并将其分为伴抑郁组和不伴抑郁组。采用阳性与阴性症状量表（Positive and Negative Syndrome Scale，PANSS）评估患者的精神症状。采用酶联免疫吸附测定（enzyme linked immunosorbent assay，ELISA）检测血清IL-6水平，并进行组间比较。采用Pearson相关分析检验血清IL-6水平与CDSS评分之间的关系。结果·依据CDSS评分结果将患者分为伴抑郁组（119例）和不伴抑郁组（120例）。与不伴抑郁组相比，伴抑郁组患者的PANSS阴性症状分量表评分、血清IL-6水平均较高（P=0.028，P=0.000）。经Pearson相关分析显示，伴抑郁组患者的血清IL-6水平与CDSS评分呈正相关（r=0.42，P=0.000）。结论·血清IL-6水平增高可能与精神分裂症伴抑郁症状的发生有关。

关键词: 精神分裂症, 白介素-6, 抑郁症状, 卡尔加里精神分裂症抑郁量表

Abstract:

Objective · To explore the relationship between serum interleukin-6 (IL-6) level and depressive symptoms in schizophrenia. Methods · A total of 239 patients with schizophrenia treated with olanzapine alone for more than 2 years were enrolled. Calgary Depression Scale for Schizophrenia (CDSS) was used to evaluate the depression level of the patients, and they were divided into depression group and non-depression group. Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms of patients. Serum IL-6 levels were measured by enzyme linked immunosorbent assay (ELISA), and the differences between the two groups were compared. Pearson correlation analysis was used to analyze the relationship between serum IL-6 level and CDSS score. Results · According to the results of CDSS, the patients were divided into depression group (119 cases) and non-depression group (120 cases). Compared with the non-depression group, the PANSS negative symptom subscale score and serum IL-6 level of patients in the depression group were higher (P=0.028, P=0.000). Pearson correlation analysis showed that serum IL-6 level was positively correlated with CDSS score in the depression group patients (r=0.42, P=0.000). Conclusion · The increase of serum IL-6 level may be related to the occurrence of schizophrenia with depression symptoms.

Key words: schizophrenia, interleukin-6 (IL-6), depressive symptom, Calgary Depression Scale for Schizophrenia (CDSS)

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