环状RNA在精神分裂症中作用的研究进展

doi:10.3969/j.issn.1674-8115.2023.11.013

上海交通大学学报（医学版） ›› 2023, Vol. 43 ›› Issue (11): 1445-1449.doi: 10.3969/j.issn.1674-8115.2023.11.013

• 综述 • 上一篇

环状RNA在精神分裂症中作用的研究进展

傅丽蓉(), 张晨()

上海交通大学医学院附属精神卫生中心，上海 200030

收稿日期:2023-05-10 接受日期:2023-10-27 出版日期:2023-11-28 发布日期:2023-11-28
通讯作者: 张晨 E-mail:fulirong_sjtu@163.com;zhangchen645@gmail.com
作者简介:傅丽蓉（1999—），女，硕士生；电子信箱：fulirong_sjtu@163.com。
基金资助:
国家自然科学基金(82271538);上海市青年科技启明星暨优秀学科带头人计划(20XD1403100);上海市科学技术委员会西医引导项目(19411969300)

Advances in the role of circular RNA in schizophrenia

FU Lirong(), ZHANG Chen()

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Received:2023-05-10 Accepted:2023-10-27 Online:2023-11-28 Published:2023-11-28
Contact: ZHANG Chen E-mail:fulirong_sjtu@163.com;zhangchen645@gmail.com
Supported by:
Natural Science Foundation of China(82271538);Shanghai Youth Science and Technology Stars and Outstanding Discipline Leaders Program(20XD1403100);Western Medicine Guide Project of Science and Technology Commission of Shanghai Municipality(19411969300)

摘要/Abstract

摘要：

精神分裂症是一种严重且复杂的精神疾病，其确切的病因尚不清楚。环状RNA（circular RNA，circRNA）是一类具有闭环结构的内源性非编码RNA，大量存在于真核细胞的转录组中。近年来，随着分子遗传领域的发展，研究者们对circRNA的表达谱和生物学作用的理解取得了巨大的进展，发现这些分子参与多种生物学过程，包括基因表达的调节、突触可塑性和认知灵活性等。研究表明circRNA在哺乳动物大脑中尤为丰富，并参与哺乳动物神经发育、维持神经功能等。细胞内外circRNA水平的改变与包括精神分裂症在内的多种神经精神疾病有关。这些特征使得circRNA在神经精神障碍方面具有独特的关键作用。基于circRNA的特性、生物学功能以及在疾病中所发挥的调控作用，越来越多的研究开始探索circRNA在精神分裂症中的异常表达及其与疾病发生发展之间的关系。其中，外泌体circRNA因具有较高的稳定性、疾病特异性以及含量丰富等特点，有望成为精神分裂症诊断潜在的生物标志物。该文就circRNA与精神分裂症的最新相关研究进展作一综述，并探讨外泌体circRNA作为精神分裂症诊断标志物、治疗靶点的可行性。

关键词: 环状RNA, 精神分裂症, 外泌体

Abstract:

Schizophrenia is a complex and severe mental disorder, the precise cause of which remains unknown. Circular RNA (circRNA), a type of non-coding RNA with a loop-like structure, is abundant in eukaryotic cell transcriptomes. Recent advancements in molecular genetics have allowed researchers to gain a better understanding of circRNA′s expression profile and biological functions. These molecules play critical roles in various biological processes, including regulation of gene expression, synaptic plasticity, and cognitive flexibility. Due to its high concentration in the mammalian brain, circRNA is involved in neurodevelopment and the maintenance of neural function. Changes in circRNA levels, both within and outside of cells, have been linked to numerous neuro-psychiatric disorders, including schizophrenia. As such, circRNA has a crucial and distinctive function in neuro-psychiatric disorders. Given its characteristics, biological functions, and regulatory roles in diseases, researchers are exploring the abnormal expression of circRNA in schizophrenia and its connection to the onset and progression of the disease. Among them, exosomal circRNA, due to its high stability, disease specificity, and abundant content, is poised to become a potential biological marker for diagnosing schizophrenia. This article provides an extensive overview of the recent circRNA and schizophrenia research, discussing the possibility of using exosomal circRNA as a diagnostic biomarker and therapeutic target for schizophrenia.

Key words: circular RNA (circRNA), schizophrenia, exosome

中图分类号:

R749.3

傅丽蓉, 张晨. 环状RNA在精神分裂症中作用的研究进展[J]. 上海交通大学学报（医学版）, 2023, 43(11): 1445-1449.

FU Lirong, ZHANG Chen. Advances in the role of circular RNA in schizophrenia[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(11): 1445-1449.

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环状RNA在精神分裂症中作用的研究进展

Advances in the role of circular RNA in schizophrenia

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