上海交通大学学报(医学版) ›› 2021, Vol. 41 ›› Issue (3): 376-379.doi: 10.3969/j.issn.1674-8115.2021.03.016

• 综述 • 上一篇    下一篇

成瘾物质线索反应性及其神经机制的研究进展

杨平原(), 江海峰, 赵敏()   

  1. 上海交通大学医学院附属精神卫生中心物质依赖与成瘾科,上海 200030
  • 收稿日期:2019-12-21 出版日期:2021-03-28 发布日期:2021-04-06
  • 通讯作者: 赵敏 E-mail:13262704708@163.com;drminzhao@gmail.com
  • 作者简介:杨平原(1991—),男,博士生;电子信箱:13262704708@163.com
  • 基金资助:
    国家自然科学基金(81771436);上海市重中之重重点学科(2017ZZ02021);上海市优秀学术带头人计划(17XD1403300);上海市卫生系统优秀人才培养计划(2017YQ013)

Research progress in cue-reactivity of addictive substance and its neural mechanism

Ping-yuan YANG(), Hai-feng JIANG, Min ZHAO()   

  1. Department of Substance Dependence and Addiction, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Received:2019-12-21 Online:2021-03-28 Published:2021-04-06
  • Contact: Min ZHAO E-mail:13262704708@163.com;drminzhao@gmail.com
  • Supported by:
    National Nature Science Foundation of China(81771436);Shanghai 'Top Priority' Key Discipline(2017ZZ02021);Program of Shanghai Academic Research Leader(17XD1403300);Shanghai Municipal Health System Excellent Talents Training Program(2017YQ013)

摘要:

成瘾物质的线索反应性是成瘾者暴露于成瘾物质相关线索时在生理、行为、脑功能等方面出现的变化和反应。线索反应性是物质成瘾的特征之一,是诱发渴求、预测复吸的重要因素,但其神经机制尚不明确。该文整理和总结了目前关于成瘾物质线索反应性神经机制的研究进展和基于线索反应性的临床治疗情况,以帮助更好地理解成瘾的发生发展,从而制定高效的临床干预策略。

关键词: 物质成瘾, 线索反应性, 条件反射, 电生理, 大脑神经环路

Abstract:

Cue-reactivity of addictive substance is a kind of evoked physiological, behavioural and neural responses when an individual is exposed to cues previously associated with addictive substance taking. Cue-reactivity is one of the main features of addiction. It can evoke craving and plays an important role in relapse. However, the neuromechanism is still unknown. The review summarizes recent research progress in the neuromechanism of cue-reactivity and the condition of clinical therapies based on cue-reactivity, which helps deeply understand the development of addiction and set effective clinical intervention strategy.

Key words: substance addiction, cue-reactivity (CR), conditioned reflex, electrophysiology, cerebral nerve circuit

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