图1 3组人群毛囊菌群的α多样性分析Note： A. Species accumulation curve. B. Venn diagrams of the OTU numbers of the three groups. C. Box plots of Chao1 index of the three groups.

Fig 1 α diversity analysis of follicular microbiome of the three groups

图2 3组人群毛囊菌群的β多样性分析Note： PCoA scatter plot based on β diversity index between samples.

Fig 2 β-diversity analysis of hair follicle microbiome of the three groups

图3 3组人群毛囊菌群在门水平上相对丰度柱状图

Fig 3 Column diagram of relative abundance of hair follicle microbiome at the phylum level in the three groups

图4 3组人群毛囊菌群在属水平上相对丰度柱状图

Fig 4 Column diagram of relative abundance of hair follicle microbiome at the genus level in the three groups

图5 C组和M组人群毛囊菌群LEfSe分析进化分支图Note： The circles radiating from the inside out represent the classification levels from phylum to genus. Each circle and its shaded range at different classification levels represent the classification at that level, and the diameter of the circle is proportional to the relative abundance of the species. The species represented by the English letters next to the circles are shown in the legend. The red nodes represent microbial communities with high abundance and important roles in the red group, the green nodes represent microbial communities with important roles in the green group, and the yellow nodes represent species with no differences between groups.

Fig 5 LEfSe cladogram of analysis of follicular microbiome in C group and M group

图6 C组和S组人群毛囊菌群LEfSe分析进化分支图Note： The circles radiating from the inside out represent the classification levels from phylum to genus. Each circle and its shaded range at different classification levels represent the classifications at those levels, and the diameter of the circle is proportional to the relative abundance of the species. The species represented by the English letters next to the circles are shown in the legend. The red nodes represent microbial communities with high abundance and important roles in the red group, the green nodes represent microbial communities with important roles in the green group, and the yellow nodes represent species with no differences between groups.

Fig 6 LEfSe cladogram of analysis of hair follicle microbiome in Group C and Group S

图7 M组和S组人群毛囊菌群LEfSe分析进化分支图Note： The circles radiating from the inside out represent the classification level from phylum to genus. Each circle and its shaded range at different classification levels represent the classification at that level, and the diameter of the circle is proportional to the relative abundance of the species. The species represented by the English letters next to the circle are shown in the legend. The red nodes represent microbial communities with high abundance and important roles in the red group, the green nodes represent microbial communities with important roles in the green group, and the yellow nodes represent species with no differences between groups.

Fig 7 LEfSe cladogram of analysis of hair follicle microbiome in Group M and Group S

图8 3组人群毛囊细菌总拷贝数箱型图

Fig 8 Box plots of total number of follicular bacterial copies of the three groups