上海交通大学学报(医学版)

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糖尿病视网膜病变中内质网应激和HIF-1对VEGF的调控机制研究进展

王 静1,朱 鸿2*,施彩虹1   

  1. 1.上海交通大学 医学院附属第三人民医院眼科, 上海 201900; 2.上海交通大学附属第一人民医院眼科, 上海 200080
  • 出版日期:2014-02-28 发布日期:2014-03-25
  • 通讯作者: 施彩虹, 电子信箱: dr_caihong@126.com。
  • 作者简介:王静(1989—), 女, 硕士生; 电子信箱: wangjing2034@126.com; 朱 鸿(1979—), 女, 博士生; 电子信箱: zhuhongchina@126.com。 *为共同第一作者。
  • 基金资助:

    上海市自然科学基金(10ZR1418500)

Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy

WANG Jing1, ZHU Hong2*, SHI Cai-hong1   

  1. 1.Department of Ophthalmology, the Third People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China; 2.Department of Ophthalmology, the First People′s Hospital, Shanghai Jiao Tong University, Shanghai 200080,  China
  • Online:2014-02-28 Published:2014-03-25
  • Supported by:

    Natural Science Foundation of Shanghai,10ZR1418500

摘要:

糖尿病视网膜病变(DR)是糖尿病严重的微血管并发症之一,可导致不可逆的失明,DR的基本病理改变是血-视网膜屏障破坏和新生血管形成,而血管内皮生长因子(VEGF)是公认的最重要的眼内新生血管生长因子。近来研究发现,内质网应激(ERS)和低氧诱导因子-1 (HIF-1)能够调控VEGF的表达,共同促进DR的病程发展。该文就ERS和HIF-1对于VEGF的调控机制方面的研究进展进行综述。

关键词: 糖尿病视网膜病变, 内质网应激, 低氧诱导因子-1, 血管内皮生长因子

Abstract:

Diabetic retinopathy is one of the most severe microvascular complications of diabetes mellitus, which can lead to irreversible blindness. The main pathological changes of DR are breakdown of blood-retinal barrier and neovascularization. Vascular endothelial growth factor (VEGF) is considered to be the most important intraocular neovascularization factor. Recent researches show that endoplasmic reticulum stress (ERS) and hypoxia-inducible factor-1 (HIF-1) can regulate the expression of VEGF and advance the progress of diabetic retinopathy together. This paper reviews the latest advance of the regulation mechanism of ERS and HIF-1 to VEGF.

Key words: diabetic retinopathy, endoplasmic reticulum stress, hypoxia-inducible factor-1, vascular endothelial growth factor