上海交通大学学报（医学版）

上海交通大学学报（医学版）

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DRD4exonⅢ基因多态性与抽动秽语综合征共病抑郁的关系

季卫东1,2，李 宁3*，郑 宏1，陈思路1，杨 闯2，周家秀2，黄晓琪2，姚 静2，郭田友2，郭兰婷2，刘协和2，吴志国4，吴 彦4，方贻儒4   

  1. 1.上海市长宁区精神卫生中心， 上海 200335； 2.四川大学 华西医院心理卫生中心， 成都 610041； 3.新乡医学院第二附属医院， 新乡 453002； 4.上海交通大学 医学院附属精神卫生中心心境障碍科， 上海 200030
  • 出版日期:2014-04-28 发布日期:2014-05-13
  • 通讯作者: 方贻儒, 电子信箱: yirufang@aliyun.com。
  • 作者简介:季卫东（1966—）， 男， 主任医师， 博士; 电子信箱: jidong1999@126.com; 李 宁（1968—）， 男， 副主任医师， 学士; 电子信箱: 13837318016@126.com。*为共同第一作者。
  • 基金资助:

    国家自然科学基金（30470624）；“十二五”国家科技支撑项目（2012BAI01B04）；上海市长宁区卫生局特色专科建设项目（2012206001）；上海市长宁区卫生局专病建设项目（2011210416）；上海市妇儿委重点项目（201208009）；上海市长宁区政府“领军人才”建设项目

Relationship between dopamine receptor D4 exon Ⅲ polymorphism and the Gilles de la Tourette syndrome comorbid with depression

JI Wei-dong1,2, LI Ning3*, ZHENG Hong1, CHEN Si-lu1, YANG Chuang2, ZHOU Jia-xiu2, HUANG Xiao-qi2, YAO Jing2, GUO Tian-you2, GUO Lan-ting2, LIU Xie-he2, WU Zhi-guo4, WU Yan4, FANG Yi-ru4   

  1. 1.Shanghai Changning Mental Health Center, Shanghai 200335, China; 2.Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China; 3.the Second Affiliated Hospital, Xinxiang Medical College, Xinxiang 453002, China; 4.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2014-04-28 Published:2014-05-13
  • Supported by:

    National Natural Science Foundation of China, 30470624; the “12th Five-year Plan” of National Key Technologies R&D Program, 2012BAI01B04; Medical Specialists Construction Project of Shanghai Changning Health Bureau,2012206001; Special Disease Contruction Project of Shanghai Changning Health Bureau,201210416; Key Project of Shanghai Women and Children Committee, 201208009; Leading Talent Construction Project of Changning District

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摘要：

目的 了解多巴胺D4受体（DRD4）基因第3外显子48 bp可重复序列多态性（DRD4 exonⅢ 48 bp VNTR）与抽动秽语综合征（TS）共病抑郁的关系。方法 选取符合美国精神疾病诊断统计手册第4版TS诊断标准的112例儿童作为研究对象（TS组），以71名健康儿童作为正常对照组。采用聚合酶链反应(PCR)等位基因分型技术检测DRD4 exonⅢ 48 bp VNTR多态位点，分析该位点与TS的关联；采用儿童抑郁量表（CDI）测定TS儿童的抑郁水平。结果 112例TS儿童中29例（25.9%）共病抑郁。TS组及其亚组DRD4 exonⅢ 48 bp VNTR位点基因型及等位基因频率与正常对照组比较，差异均无统计学意义（P>0.05）。在TS组内，携带长重复等位基因组(61例)与短重复等位基因组（51例）CDI总分和因子分比较，差异均无统计学意义（P>0.05）。结论 DRD4 exonⅢ48 bp VNTR与TS共病抑郁之间可能不存在关联。

关键词: 抽动秽语综合征, 多巴胺D4受体, 抑郁症状, 关联分析

Abstract:

Objective To investigate the relationship between the polymorphism of repeatable sequence of DRD4 exonⅢ 48 bp gene and depressive symptoms in children with Gilles de la Tourette syndrome (TS). Methods A total of 112 children who were diagnosed as TS according to the criteria of the Fourth Edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (the TS group) and 71 healthy children (the control group) were selected. The polymorphous points of DRD4 gene were genotyped by the amplification refractory mutation system (ARMS) polymerase chain reaction (PCR) genotyping assay method and the depressive levels of children with TS were measured by the children's depression inventory (CDI). Results Among 112 children with TS, 29 (25.9%) were diagnosed with depression. The differences of genotype frequency and allele frequency of DRD4 exonⅢ 48 bp VNTR among the TS group, comorbid depression group, and control group were not statistically significant (P>0.05). The differences of CDI scores and factor scores between 61 children who carried long repeat allele group and 51 children who carried short repeat allele group were not statistically significant (P>0.05). Conclusion The DRD4 exonⅢ 48 bp VNTR may not correlate to the TS comorbid depression.

Key words: Gilles de la Tourette syndrome, dopamine receptor D4, depressive symptom, association analysis