Objective To observe the clinical effects and surgical complications of Artisan iris-fixated intraocular lens (IOL) implantation for the treatment of aphakic eyes. Methods Thirteen patients (thirteen eyes) with aphakic eyes who received Artisan IOL implantation were observed. The uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), and intraocular pressure (IOP) changes of patients before and after surgeries were compared. The corneal edema, anterior chamber flash, IOL position, and iris were observed by the slitlamp microscope. The number of corneal endothelium was counted. Results The average time of follow-up was two years. The UCVA of five eyes was 0.5 or better (38.5%) and the BSCVA of six eyes was 0.5 or better (46.2%). The IOP did not change significantly before and after surgeries. There were no significant cornea edema, decentration or tilting of IOL, and inflammation of anterior chamber. The mean loss rate of endothelial cells was 10.1%. There were two eyes with the iris injury and two eyes with the iris hemorrhage during the surgery, but were absorbed shortly after the surgery. There was one eye with IOL dislocation during the follow-up and the IOL was refixed. No macular edema was observed. Conclusion Artisan irisfixated IOL implantation is a safe and effective method for treating aphakic eyes. The surgery is simple with less damage to tissues and less complications. The postoperative visual acuity can be significantly improved.