上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

32磷-胶体介入治疗甲状腺瘤的临床观察

王 舰，楼 岑   

  1. 浙江大学医学院附属邵逸夫医院核医学科， 杭州 310020
  • 出版日期:2015-01-28 发布日期:2015-01-29
  • 基金资助:

    王舰(1979—)， 男， 住院医师， 硕士; 电子信箱: wj_791216@163.com。

Clinical observation of interventional therapy of thyroid tumor by 32Phosphorus-radiocolloid

WANG Jian, LOU Cen   

  1. Department of Nuclear Medicine, Sir Run Run Shaw Hospital Affiliated to School of Medicine, Zhejiang University, Hangzhou 310020, China
  • Online:2015-01-28 Published:2015-01-29

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摘要：

目的 观察超声引导下的核素32磷-胶体（32P-胶体）瘤体内注射介入治疗甲状腺瘤的效果。方法 以分别接受32P-胶体瘤体内注射介入治疗（32P-胶体组，n=30
）和超声引导下经皮穿刺瘤内无水乙醇注射治疗（对照组，n=30）的甲状腺瘤患者作为研究对象。分别于治疗后2、4、6、8个月时随访疗效及不良反应的发生情况。结果 治疗后定期随访发现，32P-胶体组患者接受治疗6个月和8个月后的疗效与瘤体大小有关（P=0.042，P=0.019）；治疗后8个月，32P-胶体组疗效显著优于对照组(P=0.011)。32P-胶体组的不良反应主要为肿瘤部位轻度胀痛（33.00%）、局部皮肤发红（16.67%）及放射性皮炎（6.70%）。结论 超声引导下32P-胶体瘤体内注射介入治疗甲状腺腺瘤，操作简便、效果显著且不良反应少；其疗效与瘤体大小有关。

关键词: 甲状腺瘤, 32P放射性同位素, 介入治疗

Abstract:

Objective To observe the effects of interventional therapy on the thyroid tumor by intratumoral injection of 32Phosphorus-radiocolloid (32P-colloidal) under ultrasonic guidance. Methods Patients with thyroid tumors who underwent intratumoral injection of 32P-colloidal (32P-colloidal group, n=30) and pure ethanol (control group, n=30) under ultrasound guidance were selected. The therapeutic effect and adverse reactions were recorded by follow-up after being treated for 2, 4, 6, and 8 months. Results Regular follow-up showed that the therapeutic effect of 32P-colloidal group was correlated with the tumor size after being treated for 6 and 8 months (P=0.042 and 0.019, respectively). The therapeutic effect of 32P-colloidal group was significantly better than that of the control group after being treated for 8 months (P=0.011). The main adverse reactions of 32P-colloidal group were mild pain at tumors sites (33.00%), local skin erubescence (16.67%), and radiodermatitis (6.70%). Conclusion The interventional therapy of thyroid tumor by intratumoral injection of 32P-colloidal under ultrasonic guidance is convenient and effective with less adverse reactions. The therapeutic effect is correlated with the tumor size.

Key words: thyroid tumor, 32Phosphorus radioisotope, interventional therapy