上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

男性代谢综合征人群血清γ-谷氨酰转肽酶水平与高尿酸血症的相关性

顾静莉，曹勤，黄融，顾伟威，马嘉骅，范竹萍   

  1. 上海交通大学 医学院附属仁济医院健康保健中心， 上海 200127
  • 出版日期:2015-08-28 发布日期:2015-09-30
  • 通讯作者: 范竹萍, 电子信箱: zhuping_fan@163.com。
  • 作者简介:顾静莉（1980—）， 女， 主治医师， 硕士; 电子信箱: renjigjl@163.com。

Correlation between γ-glutamyltransferase and hyperuricemia of male populations with metabolic syndrome

GU Jing-li, CAO Qin, HUANG Rong, GU Wei-wei, MA Jia-hua, FAN Zhu-ping   

  1. Department of Health Care Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2015-08-28 Published:2015-09-30

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摘要：

目的  探讨男性代谢综合征(MS)人群中血清γ-谷氨酰转肽酶(GGT)不同水平对高尿酸血症(HUA)的影响程度。方法  纳入2012年1—12月上海地区某三甲医院体检中心11 427例男性人群为研究对象，其中MS患者（MS组）2 908例，正常对照组8 519例。检测受试者体质指数（BMI）、收缩压（SBP）和舒张压（DBP）、尿酸(SUA)、丙氨酸氨基转移酶（ALT）、血GGT、空腹血糖（FPG）、三酰甘油（TAG）、总胆固醇（T-Ch）、高密度脂蛋白胆固醇（HDL-Ch）、低密度脂蛋白胆固醇（LDL-Ch）。将GGT按照四分位法分为四组，比较两组高四分位组与低四分位组对HUA的影响程度，多因素分析采用非条件Logistic回归。结果  MS组的BMI、SBP、DBP、SUA、ALT、GGT、FPG、TAG 、T-Ch、LDL-Ch水平均显著高于正常对照组（P<0.001），HDL-Ch显著低于正常对照组（P<0.001），脂肪肝患病率显著高于正常对照组（P<0.001）；MS组与正常对照组上述各相关因素在GGT高四分位组与低四分位组间的差异具有统计学意义（P<0.05）。在MS组，进行多因素校正后，与GGT低四分位组比较，GGT高四分位组HUA发生风险的OR值为3.09（P<0.01）；在对照组，与GGT低四分位组比较，GGT高四分位组HUA发生风险的OR值为2.17（P<0.01）。结论  在男性MS人群，GGT水平的升高能反映其HUA的发生风险明显增加；即使在MS各组分均正常的男性人群中，这种发生风险同样增加，提示在临床和预防上要重视对GGT的健康管理，关注GGT水平及其动态变化，及时干预并警惕相关疾病的发生发展。

关键词: &gamma, -谷氨酰转肽酶；高尿酸血症；代谢综合征；危险因素

Abstract:

Objective  To investigate the effects of different levels of serum γ-glutamyltransferase (GGT) of male patients with metabolic syndrome (MS) on hyperuricemia (HUA). Methods  A total of 11 427 male adults who underwent the physical examination from January to December, 2012 at the physical examination center of a third level grade A hospital were selected as subjects and divided into the MS group (n=2 908) and normal control group (n=8 519). Their BMI, SBP, DBP, SUA, ALT, GGT, FPG, T-Ch, TAG, HDL-Ch, and LDL-Ch were measured. According to the GGT level, subjects were divided into 4 groups based on the quartile method. The effects of high quartile groups and low quartile groups on HUA were compared and multivariate non conditional Logistic regression analysis was adopted. Results  Compared with the normal control group, mean levels of BMI, SBP, DBP, SUA, ALT, GGT, FPG, TAG, T-Ch, and LDL-Ch of the MS group were significantly higher (P<0.001), HDL-Ch was significantly lower (P<0.001), and the incidence of fatty liver was significantly higher (P<0.001). The differences of above indexes of high quartile groups and low quartile groups were statistically significant (P<0.05). For the MS group, compared with low quartile groups, the OR value of the risk of HUA of high quartile groups was 3.09 after the indexes were corrected (P<0.01). For the normal control group, compared with low quartile groups, the OR value of the risk of HUA of high quartile groups was 2.17 (P<0.01). Conclusion  For male population with MS, the increase of GGT level indicates significant increase of the risk of HUA. Even for male population with normal components of MS, the risk of HUA also increases with the GGT level. So for clinical treatment and protection, more attention should be paid to the health management of GGT, including its level and dynamic change. Timely intervention should be performed and the incidence and development of relevant diseases should be concerned.

Key words: &gamma, -glutamyltransferase； hyperuricemia； metabolic syndrome； risk factor