上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 综述 • 上一篇    

凋亡抑制蛋白Livin在肿瘤中的作用及其诊断和治疗应用进展

马大骅，黄楷，姜梦迪，徐菲菲，管艺贝，程枫   

  1. 上海交通大学 医学院基础医学教学实验中心， 上海 200025
  • 出版日期:2016-05-28 发布日期:2016-05-26
  • 通讯作者: 程枫, 电子信箱: jychengf@shsmu.edu.cn。
  • 作者简介:马大骅(1994—)， 女， 临床八年制学生; 电子信箱: madahua0521@163.com。

Effects of the inhibitor of apoptosis protein Livin in tumors and research progresses of the application of Livin to the diagnosis and treatment of tumors

MA Da-hua, HUANG Kai, JIANG Meng-di, XU Fei-fei, GUAN Yi-bei, CHENG Feng   

  1. Experimental Center of Basic Medicine Teaching，Shanghai Jiao Tong University， Shanghai 200025， China
  • Online:2016-05-28 Published:2016-05-26

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摘要：

凋亡异常是引起正常细胞向癌细胞转化的原因之一。凋亡抑制蛋白（IAPs) 是一类高度保守的内源性抗凋亡因子，在癌症的发生和发展中具有重要作用。Livin蛋白是IAPs新成员，对肿瘤生长、转移和侵袭等有明显促进作用，同时也是调控肿瘤对化疗药物敏感性的关键分子，故可成为重要的肿瘤分子标志物和潜在治疗靶点。该文综述Livin在消化、泌尿、生殖等多系统肿瘤中的表达情况、作用机制及应用于肿瘤诊断和治疗的研究进展。

关键词: Livin, 肿瘤, 凋亡调节, 抗肿瘤治疗

Abstract:

Abnormal apoptosis is one of causes leading to the transformation of normal cells towards cancer cells. Inhibitors of apoptosis proteins (IAPs), a group of endogenous cytokines which inhibit apoptosis, play a vital role in the occurrence and development of cancer. Livin is a new member of IAPs family and significantly promotes the growth, metastasis, and invasion of tumors. It is also a key factor for regulating the sensitivity of tumors towards chemotherapeutic agents. Therefor Livin can serve as an important molecular marker and a potential therapeutic target for tumors. This paper reviews research progresses of the expression and acting mechanisms of Livin in tumors in digestive, urinary, and reproductive systems and application of Livin to the diagnosis and treatment of tumors.

Key words: Livin, tumor, regulation of apoptosis, anti-tumor therapy