上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（基础研究） • 上一篇    下一篇

41 ℃及43 ℃温热疗联合聚乙二醇化脂质体阿霉素治疗兔VX2肿瘤的疗效对比研究

 丁昂昂1，熊屏1，沈国峰2，陈亚珠2   

  1. 上海交通大学 1.医学院附属第九人民医院超声医学科， 上海 200011； 2.生物医学工程学院， 上海 200030
  • 出版日期:2016-06-28 发布日期:2016-07-25
  • 通讯作者: 熊屏, 电子信箱: xiong_ping_xp@163.com。
  • 作者简介:丁昂昂（1990—）， 女， 硕士生; 电子信箱: dingangang1205@163.com。
  • 基金资助:

    国家自然科学基金（81272567）

Comparative study on efficacy of 41 ℃ or 43 ℃ mild hyperthermia with pegylated liposomal doxorubicin for treatment of rabbit VX2 tumor

DING Ang-ang1, XIONG Ping1, SHEN Guo-feng2, CHEN Ya-Zhu2   

  1. 1.Department of Ultrasound, Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; 2.School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200230, China
  • Online:2016-06-28 Published:2016-07-25
  • Supported by:

    National Natural Science Foundation of China， 81272567

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摘要：

目的 探讨41 ℃及43 ℃温热疗（MH）触发聚乙二醇化脂质体阿霉素（PLD）释放阿霉素治疗兔VX2肿瘤的疗效差异。方法 12只VX2移植瘤兔随机分为2组：PLD+41 ℃ MH组(n=6)和PLD+43 ℃ MH组(n=6)。为达到完全的肿瘤缓解，进行多次高剂量耳缘静脉推注给药（5 mg/kg，每周1次，共治疗3次），使用嵌入式超声温热治疗仪对肿瘤部位进行30 min局部MH。结果 在观察终点，PLD+41 ℃ MH组血管形成指数（VI）、瘤体质量、外周血谷草转氨酶（GOT）、乳酸脱氢酶(LDH)、肌酸激酶(CPK)值均明显低于PLD+43 ℃ MH组。结论 同43 ℃下30 min MH相比，41 ℃下30 min MH联合PLD可以明显提高抗肿瘤疗效，降低系统毒性。

关键词: 聚乙二醇化脂质体阿霉素, 温热疗, VX2肿瘤模型

Abstract:

Objective To investigate the difference in efficacy between doxorubicin released by 41 ℃ and 43 ℃ mild hyperthermia (MH) triggered-pegylated liposomal doxorubicin (PLD) for the treatment of rabbit VX2 tumor. Methods Twelve rabbits with VX2 tumor transplanted into the superficial muscle of the hind limb were randomly assigned to 2 groups, i.e. the 41 ℃ MH+PLD group (n=6) and the 43 ℃ MH+PLD group (n=6). To achieve complete tumor remission, multiple high-dose administrations (5 mg/kg, once per week for 3 weeks) were given by intravenous injection. An embedded ultrasound tumor hyperthermia instrument was used to perform local MH at tumor sites for 30 min. Results At the endpoint, the 41 ℃ MH+PLD group had lower vascularization index, tumor weight, and levels of GOT, LDH and CPK in peripheral blood as compared with the 43 ℃ MH +PLD group. Conclusion In comparison with 43 ℃ MH for 30 min, 41 ℃ MH for 30 min plus PLD can significantly improve the antitumor efficacy, and reduce the systemic toxicity.

Key words: pegylated liposomal doxorubicin, mild hyperthermia, VX2 tumor model