上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

2型糖尿病患者人体成分与肾损害指标的相关性研究

顾婷，姜博仁，韩兵，仰礼真   

  1. 上海交通大学 医学院附属第九人民医院内分泌代谢科， 上海 200011
  • 出版日期:2016-06-28 发布日期:2016-07-25
  • 通讯作者: 仰礼真, 电子信箱: dryanginsh@yahoo.com。
  • 作者简介:顾婷（1981—）， 女， 主治医师， 硕士; 电子信箱: xiaoguting2013@126.com。
  • 基金资助:

    上海交通大学医学院附属第九人民医院院级基金（2013B13）

Study on the correlation between body composition and renal damage indexes in patients with type 2 diabetes mellitus

GU Ting, JIANG Bo-Ren, HAN Bing, YANG Li-Zhen   

  1. Department of Endocrinology and Metabolism, Shanghai Ninth Peoples Hospital， Shanghai Jiao Tong University School of Medicine, Shanghai  200011, China
  • Online:2016-06-28 Published:2016-07-25
  • Supported by:

    The Research Project Fund of Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, 2013B13

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摘要：

目的 研究2型糖尿病患者人体成分与肾损害指标的相关性。方法 随机选取2型糖尿病患者100例作为研究对象,其中男性45例，女性55例。应用人体成分分析仪测定人体成分相关指标（体脂肪率、肌肉率、体内水分比率等），并对肾损害相关指标（血尿素氮、尿酸、肌酐、估算的肾小球滤过率及24 h尿蛋白、尿微量白蛋白、尿β2微球蛋白、尿N-乙酰-β-D-氨基葡萄糖苷酶及转铁蛋白等）进行检测，分析2组参数的相关性。结果 在男性患者，血清尿酸水平与体脂肪率呈正相关，与肌肉率呈负相关；24 h尿蛋白与细胞外液率呈负相关。在女性患者，血清尿酸与体脂肪率呈正相关，与肌肉率和细胞外液率呈负相关；24 h尿蛋白与体脂肪率呈正相关，与肌肉率和细胞外液率呈负相关。结论 体脂肪率、肌肉率、体内水分比率等可能是影响尿酸和蛋白尿的重要因素，与糖尿病肾损害相关。

关键词: 2型糖尿病, 人体成分, 尿酸, 蛋白尿

Abstract:

Objective To investigate the correlation between body composition and renal damage indexes in patients with type 2 diabetes mellitus. Methods One hundred patients with type 2 diabetes mellitus were randomly enrolled, including 45 male ones and 55 female ones. The body composition related parameters (including body fat percent, body muscle percent, and body water percent, etc.) were measured with a body composition analyzer and renal damage related parameters (including serum urea nitrogen, uric acid, creatinine, estimated glomerular filtration rate, 24 hours urine protein, microalbumiuria, urinary beta2 microglobulin, N-acetyl-beta-D-glucosaminidase, and transferrin, etc.) were detected. The correlation between body composition and renal damage indexes was analyzed. Results For male patients, the serum uric acid level was positively correlated to the body fat percent and negatively correlated to the body muscle percent, and the 24 hours urine protein was negatively correlated to the extracellular water percent. For female patients, the serum uric acid was positively correlated to the body fat percent and negatively correlated to the body muscle percent and the extracellular water percent, and 24 hours urine protein was positively correlated to the body fat percent and negatively correlated to the body muscle percent and extracellular water percent. Conclusion Body fat percent, body muscle percent, and body water percent may be important factors influencing uric acid and proteinuria, which are associated with renal damage in patients with type 2 diabetes mellitus.

Key words: type 2 diabetes, body composition, uric acid, proteinuria