上海交通大学学报（医学版）

上海交通大学学报（医学版）

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抑郁症脑结构影像学研究进展

周儒白， 赵国庆， 林晔喆， 方贻儒   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科， 上海 200030
  • 出版日期:2016-10-28 发布日期:2016-11-29
  • 通讯作者: 方贻儒， 电子信箱： yirufang@gmail.com。
  • 作者简介:周儒白（1991—）， 女, 博士生； 电子信箱: zhourubai@foxmail.com。
  • 基金资助:

    国家自然科学基金（91232719）；国家临床重点专科-上海市精神卫生中心（卫生部医政司2011-873）；“十二五”国家科技支撑项目(2012BAI01B04)

Advances in structural neuroimaging studies on major depressive disorders

ZHOU Ru-bai, ZHAO Guo-qing, LIN Ye-zhe, FANG Yi-ru   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2016-10-28 Published:2016-11-29
  • Supported by:

    National Natural Science Foundation of China， 91232719； National Key Clinical Disciplines at Shanghai Mental Health Center， OMA-MH, 2011-873；National Key Technology Research & Development Program of the Ministry of Science and Technology of China in the “12th Five-year Plan”， 2012BAI01B04

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摘要：

脑结构影像学是精神障碍研究的一个重要领域，其中磁共振检查在抑郁症研究中应用广泛。目前抑郁症的结构影像学研究的结论尚未达成一致，测量变量亦有很大局限性，不足以应用于临床实践。利用磁共振成像测量抑郁症患者的脑区体积及皮层厚度、表面积、皮层折叠系数等新变量，可以分析抑郁症患者发病时及疾病发展过程中的脑结构改变。该文关注抑郁症病因、诊断、治疗、预后等方面，按脑区对抑郁症患者脑部的结构影像学研究进行综述，介绍该领域的研究进展。

关键词: 抑郁症, 磁共振成像, 结构

Abstract:

Structural neuroimaging is an important field in mental disorder researches and magnetic resonance imaging (MRI) is widely used for studying major depressive disorders (MDD). However, no consensus has been reached in structural neuroimaging researches on depression and measured variables have many limitations, so it is not suitable for clinical practices. This study analyses brain structural changes during onset and development of MDD using MRI via new variables such as brain volume, cortical thickness, surface area, and hypergyrification. This article focuses on etiology, diagnosis, treatment, as well as prognosis of MDD, and reviews structural neuroimaging researches according to brain regions, so as to introduce clinical advances in this field.

Key words: major depressive disorder, magnetic resonance imaging, structure