上海交通大学学报(医学版)

• 论著(临床研究) • 上一篇    下一篇

残余胆固醇在急性冠脉综合征患者评估中的应用

汪萍,毛剑虹,陆一闻,沈立松   

  1. 上海交通大学 医学院附属新华医院检验科,上海 200092
  • 出版日期:2016-12-28 发布日期:2016-12-29
  • 通讯作者: 沈立松,电子信箱:lisongshen@hotmail.com。
  • 作者简介:汪萍(1974—),女,副主任技师,硕士;电子信箱:pink_wangping@163.com。
  • 基金资助:

    上海市科委生物医药领域产学研医合作项目(14DZ1940200, 14DZ1940203)

Application of residual cholesterol to the assessment of patients with acute coronary syndrome

WANG Ping, MAO Jian-hong, LU Yi-wen, SHEN Li-song   

  1. Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2016-12-28 Published:2016-12-29
  • Supported by:

    Production-Study-Research-Medical Cooperation Science and Technology Commission of Shanghai Municipality, 14DZ1940200, 14DZ1940203

摘要:

目的 ·研究残余胆固醇(RC)水平对急性冠脉综合征(ACS)患者的临床应用评估。方法 ·利用生化法检测293例稳定型心绞痛患者、115例非高血压的ACS患者、72例合并高血压的ACS患者、91例疾病对照组患者和152例表观健康人群的总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-Ch)和低密度脂蛋白胆固醇(LDL-Ch)水平。RC由TC减去HDL-Ch和LDL-Ch得到,非高密度脂蛋白胆固醇(non-HDL-Ch)由TC减去HDL-Ch得到。对RC与TC、LDL-Ch、HDL-Ch、non-HDL-Ch的相关性进行分析。利用ROC曲线分析RC、LDL-Ch、non-HDL-Ch在鉴别稳定型心绞痛组和ACS中的作用。结果 · ACS组、ACS合并高血压组的RC均显著高于稳定型心绞痛组(P<0.05)。RC与TC、LDL-Ch、HDL-Ch和non-HDL-Ch相关性均有统计学意义(均P<0.01)。稳定型心绞痛及ACS患者的ROC曲线分析表明, RC对于鉴别该2种疾病最佳,以下依次为non-HDL-Ch、LDL-Ch、TC、HDL-Ch。结论 · RC水平在缺血性心脏病患者中明显升高,可作为ACS与稳定型心绞痛的鉴别指标。

关键词: 残余胆固醇, 急性冠脉综合征, 缺血性心脏病

Abstract:

Objective · To investigate the clinical application of serum remnant cholesterol (RC) to the assessment of patients with acute coronary syndrome (ACS). Methods · We enrolled 293 patients with stable angina (SA), 115 patients with non-hypertensive ACS, 72 patients with hypertensive ACS, 91 patients as controls, and 152 healthy controls. Levels of total cholesterol (TC), HDL- cholesterol (HDL-Ch), and LDL-Ch were measured with biochemistry method. RC was given by subtracting LDL-Ch and HDL-Ch from TC and non-HDL-Ch was given by subtracting HDL-Ch from TC. The correlations of RC with TC, LDL-Ch, HDL-Ch, and non-HDL-Ch were analyzed. ROC curves were used to analyze the application of RC, LDL-Ch, HDL-Ch, and non-HDL-Ch for differentiating SA and ACS. Results · The RC level was significantly higher in the ACS group and the hypertensive ACS group than in the SA group (P<0.05). Correlations of RC with TC, LDL-Ch, HDL-Ch, and non-HDL-Ch were statistically significant (P<0.01). The ROC curve analysis showed that RC was the best for differentiating SA and ACS, followed by non-HDL-Ch, LDL-Ch, TC, and HDL-Ch. Conclusion · Remnant cholesterol is significantly elevated in the patients with ischemic heart disease and can be used for differentiating ACS and stable angina.

Key words:  remnant cholesterol, ischemic heart disease, acute coronary syndrome