上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

术前外周血中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值对卵巢癌患者预后评估的意义

张立伟，潘慧颖，姚晓天，王天勤，周小欣，王育   

  1. 上海交通大学 医学院附属仁济医院妇产科，上海 200127
  • 出版日期:2017-05-28 发布日期:2017-05-31
  • 通讯作者: 王育，电子信箱：renjiwangyu@126.com。
  • 作者简介:张立伟（1990—），女，硕士生；电子信箱：15000051920@163.com。
  • 基金资助:

    国家自然科学基金（81572560）

Prognostic significance of preoperative peripheral blood neutrophil/lymphocyte ratio and platelet/ lymphocyte ratio in patients with ovarian cancer

ZHANG Li-wei, PAN Hui-ying, YAO Xiao-tian, WANG Tian-qin, ZHOU Xiao-xin, WANG Yu   

  1. Department of Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2017-05-28 Published:2017-05-31
  • Supported by:

    National Natural Science Foundation of China，81572560

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摘要：

目的 ·探讨卵巢癌患者术前外周血中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）与临床病例特征及预后的关系。方法 ·收集127例卵巢良性肿瘤患者及286例卵巢恶性肿瘤患者的临床资料，分析NLR、PLR与临床病理之间的相关性及其与患者总体生存期（OS）之间的关系。结果 ·卵巢癌患者术前 NLR、PLR水平均高于良性肿瘤的患者(P=0.000)。NLR、PLR的最佳截点分别为3.0和151。NLR高水平组（NLR ≥3.0）患者的病理类型、FIGO分期、淋巴结转移、CA125水平及腹水量与NLR低水平组比较，差异具有统计学意义(P<0.05)；PLR高水平组（PLR ≥151）患者的病理类型、FIGO分期、有无转移、CA125水平及腹水量与PLR低水平组比较，差异具有统计学意义（P<0.05）。NLR、PLR高水平组的中位OS（33个月和33.5个月）分别低于相应的低水平组（44.5个月和 49.5个月），差异均有统计学意义（P=0.044和P=0.000）。Cox多因素分析显示，PLR ≥151是卵巢癌患者OS的独立危险因素(HR为1.936，95% CI为1.013～
3.698, P=0.045)。结论 ·术前炎症指标NLR、PLR与卵巢癌患者的临床病理特征及生存预后有着密切的关系，有望用于预估患者病情及指导卵巢癌治疗。

关键词: 中性粒细胞/淋巴细胞比值；血小板/淋巴细胞比值, 卵巢肿瘤；预后

Abstract:

Objective · To explored the correlation of preoperative peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) with clinical characteristics and prognosis of ovarian cancer. Methods · Patients’ clinicopathological data of 127 cases of benign tumors and 286 cases of malignant tumor were collected, and the correlation between the level NLR and PLR in patients with ovarian cancer clinical pathology indicators and overall survival was analyzed. Results · preoperative NLR and PLR levels in patients with ovarian cancer were higher than those in benign tumors(P=0.000). The optimal cut-off point of NLR and PLR were 3.0 and 151. There was statistical significant difference between the high level of NLR group (NLR≥ 3) and the low level of NLR group in pathological type, FIGO staging, lymph node metastasis, CA125 level and the amount of ascites (P<0.05). There was statistical significant difference between the high level of PLR group (PLR≥151) and the low level of PLR group in FIGO stage, transfer status, CA125 level and quantity of ascites (P<0.05). The median survival time for NLR/PLR in the high level group were 33 and 33.5 months lower than that of the corresponding group of 44.5 and 49.5 months (P=0.044, P=0.000). Multivariate Cox regression analysis showed that PLR ≥ 151 were independent risk factors affect OS in ovarian cancer patients (HR=1.936, 95% CI=1.013-3.698, P=0.045). Conclusion · The elevated blood preoperative PLR indicates poor prognosis of ovarian cancer patients. Preoperative PLR may serve as an important independent prognostic factor for ovarian cancer patients.

Key words: neutrophil / lymphocyte ratio, platelet / lymphocyte ratio, ovarian neoplasm, prognosis