上海交通大学学报（医学版）

上海交通大学学报（医学版）

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间充质干细胞成骨分化中多种调控因子的交互作用及其机制

陈晓婷，高艳虹   

  1. 上海交通大学 医学院附属新华医院老年医学科，上海 200092
  • 出版日期:2017-05-28 发布日期:2017-05-31
  • 通讯作者: 高艳虹，电子信箱：yhgao2010@yahoo.com。
  • 作者简介:陈晓婷（1992—），女，硕士生；电子信箱：lemon-tree@sjtu.edu.cn。
  • 基金资助:

    国家自然科学基金（81101360）；上海市科委自然科学基金（16ZR1422000）；教育部归国留学人员启动基金（20134701）

Interaction and mechanism of various regulatory factors in osteogenic differentiation of mesenchymal stem cells

CHEN Xiao-ting, GAO Yan-hong   

  1. Department of Geriatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2017-05-28 Published:2017-05-31
  • Supported by:

    National Natural Science Foundation of China, 81101360；Natural Science Foundation of Science and Technology Committee of Shanghai Municipality, 16ZR1422000; Scientific Research Foundation for the Returned Overseas Chinese Scholars, 20134701

PDF (PC)

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摘要：

间充质干细胞（MSCs）分化为成骨细胞是骨代谢和骨修复的重要环节，其机制复杂。目前研究发现骨形态发生蛋白（BMP）、成纤维细胞生长因子（FGF）、Wnt、Hedgehog、NELL1、胰岛素样生长因子（IGF）和Notch等多种信号分子参与调控MSCs的成骨分化过程。这些信号分子自身都被证明具有较强的促进 MSCs成骨分化的能力。它们能通过特异性配体激活相应受体，从而开启胞内特异的信号转导通路，促进成骨相关基因的转录、翻译过程。同时，各个信号通路之间又形成复杂的调控网络，彼此影响，共同调控MSCs的成骨分化过程。对这些信号通路相互作用机制的深入研究对于推动骨组织工程发展及治疗骨代谢疾病有重要意义。

关键词: 信号通路, 间充质干细胞, 成骨分化

Abstract:

Osteogenic differentiation of mesenchymal stem cells (MSCs) is an important link of bone metabolism and bone repair, the mechanism of which is usually complicated. Recent studies have found that BMP, FGF, Wnt, Hedgehog, NELL1, IGF, Notch and other signaling molecules are involved in the regulation of osteogenic differentiation of MSCs. These signaling molecules themselves have been shown to have a strong ability to promote osteogenic differentiation. They can activate the corresponding receptors by specific ligands, thus initiating the specific signal transduction pathways in the cell, and finally promote the transcription and translation of the genes related to bone formation. Furthermore, all the signaling pathways form a complex network which regulates and influences the osteogenic differentiation of MSCs. Further researches on the mechanism of the interaction of these signaling pathways is of great significance in promoting the development of bone tissue engineering and the treatment of bone metabolic diseases.

Key words: signaling pathway, mesenchymal stem cells, osteogenic differentiation