上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (9): 1089-.doi: 10.3969/j.issn.1674-8115.2019.09.024

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经颅直流电刺激治疗强迫症的研究进展

程佳月，王振   

  1. 上海交通大学医学院附属精神卫生中心，上海 200030
  • 出版日期:2019-09-28 发布日期:2019-11-02
  • 作者简介:程佳月（1994—）女，硕士生；电子信箱： chengjy_94@163.com。
  • 基金资助:
    国家自然科学基金（81671340）；上海市卫生计生系统优秀学科带头人培养计划（2017BR058）；上海市教育委员会高峰高原学科建设计划（20161321）

Progress of transcranial direct current stimulation for treatment of obsessive-compulsive disorder

CHENG Jia-yue, WANG Zhen   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2019-09-28 Published:2019-11-02
  • Supported by:
    National Natural Science Foundation of China, 81671340; Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines in Shanghai, 2017BR058; Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Support, 20161321）。

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摘要： 强迫症是一种以反复持久出现强迫观念或强迫行为为基本特征的致残性疾病，目前的一线治疗方法主要包括药物治疗和心理治疗以及二者联合使用，但仍有将近 40%的患者对于这些治疗无反应。在近期发展的治疗方法中，非侵入性脑刺激技术，如经颅直流电刺激（ transcranial direct current stimulation，tDCS）有望缓解多种精神疾病的症状并改善认知功能。 tDCS已应用于抑郁症、精神分裂症、普遍性焦虑以及其他精神心理疾病的治疗中，并取得确切的临床疗效。但有关 tDCS技术治疗强迫症的研究较少，尤其是随机对照研究数量少，多为开放性试验或案例报道，且结果存在不一致性。该文回顾现有报道中 tDCS治疗强迫症患者的效果，分析未来将 tDCS广泛应用于治疗强迫症患者的可能性。

关键词: 强迫症, 经颅直流电刺激, 非侵入性脑刺激, 神经调节

Abstract:

Obsessive-compulsive disorder is a disabling disease with symptoms of repeated and persistent unwanted intrusive thoughts and compulsive behaviors. The current first-line treatment methods mainly include psychopharmacology, psychotherapy, and the combination of both, but nearly 40% patients still show no response to conventional treatment. Among the recently developed treatments, non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), are expected to alleviate the symptoms of various psychiatric disorders and improve cognitive function. tDCS has been applied to the treatment of depression, schizophrenia, generalized anxiety disorder and other mental diseases, and has achieved definite clinical effect. However, there are few studies about tDCS applying to the obsessive-compulsive disorder, especially in the number of randomized controlled trials. Most of the studies are open trials and case reports, and the results are inconsistent.reviewing the effect of tDCS in treating obsessive-compulsive disorder patients in existing reports, the possibility of applying tDCS widely to treating obsessive-compulsive disorder in the future is analyzed.

Key words: obsessive-compulsive disorder, transcranial direct current stimulation, non-invasive brain stimulation techniques, neuromodulation

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