上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2020, Vol. 40 ›› Issue (4): 539-.doi: 10.3969/j.issn.1674-8115.2020.04.021

• 综述 • 上一篇    下一篇

经皮迷走神经刺激术研究进展

顾楠楠1，李春波1, 2, 3, 4   

  1. 1. 上海交通大学医学院附属精神卫生中心，上海200030；2. 上海交通大学心理与行为科学研究院，上海200030；3. 上海交通大学脑科学与技术研究中心，上海200030；4. 中国科学院脑科学与智能技术卓越创新中心，上海200030
  • 出版日期:2020-04-28 发布日期:2020-05-22
  • 通讯作者: 李春波，电子信箱：licb@shmc.org.cn。
  • 作者简介:顾楠楠（1991—），女，博士生；电子信箱：gnnsjtu@163.com。
  • 基金资助:
    上海市精神卫生中心临床研究中心重点项目（CRC2017ZD01）。

Research progresses in transcutaneous vagus nerve stimulation

GU Nan-nan, LI Chun-bo   

  1. 1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai 200030, China; 3. Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai 200030, China; 4. Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai 200030, China
  • Online:2020-04-28 Published:2020-05-22
  • Supported by:
    Key Program of Clinical Research Center in Shanghai Mental Health Center (CRC2017ZD01).

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摘要： 迷走神经（vagus nerve，VN）在人类炎症、情绪和疼痛调节中均有参与，刺激迷走神经对治疗难治性癫痫和难治性抑郁症有一定效果。耳甲区是人类体表唯一具有迷走神经传入纤维分布的区域。根据神经系统遵循“自下而上”的信号传递加工机制，刺激外周神经可调节中枢神经系统的功能。因此，刺激迷走神经耳支这一外周通路可以调节脑干、丘脑、大脑皮层等相关区域的活动，从而达到治疗目的。经皮迷走神经刺激术（transcutaneous vagus nerve stimulation，tVNS）是一种基于此解剖特点由迷走神经刺激术发展而来的安全、低成本、非侵入性的物理疗法。此综述主要阐述了经皮迷走神经刺激术对器官功能的调节作用及其在疾病治疗中的应用。

关键词: 经皮迷走神经刺激术, 物理疗法, 功能调节, 临床应用

Abstract:

The vagus nerve is involved in the regulation of human inflammation, mood and pain. Stimulation of the vagus nerve has assured therapeutic effects on intracepilepsy and refractory depression. On the surface of the human body, the ear is the only area in which vagal afferent fibers distribute. According to the "bottom-up" mechanism of the signal processing, the central nervous system can be modulatedstimulating the peripheral nerve. Therefore, stimulation of the vagus nerve can regulate the activities of brain stem, thalamus, cerebral cortex and other related areas to produce therapeutic effects. Transcutaneous vagus nerve stimulation is a safe, low-cost, non-invasive physical therapy modified vagus nerve stimulation. This review focuses on the regulation of organ functiontranscutaneous vagus nerve stimulation and its application to diseases treatment.

Key words: transcutaneous vagus nerve stimulation, physical therapy, functional regulation, clinical application