上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (09): 1207-1212.doi: 10.3969/j.issn.1674-8115.2020.09.007

• 论著·临床研究 • 上一篇    下一篇

精神分裂症快感缺失特征及其影响因素分析

余玲芳1，方新宇2，陈 艳1，王丹丹1，汪也微1，吴则南1，刘瑞梅1，张 晨1   

  1. 1. 上海交通大学医学院附属精神卫生中心生化药理研究室，上海200030；2. 南京医科大学附属脑科医院，南京210029
  • 出版日期:2020-09-28 发布日期:2020-11-04
  • 通讯作者: 张 晨，电子信箱：zhangchen645@gmail.com。
  • 作者简介:余玲芳（1994—），女，硕士生；电子信箱：yulingfang1222@163.com。
  • 基金资助:
    国家重点研发计划（2018YFC1314302）；国家自然科学基金（81471358，81771450）；上海市科学技术委员会西医引导类项目（14411969000）；上海市教育委员会高峰高原学科建设计划（20152530）；上海市卫生与计划生育委员会科研项目（201540029）。

Analysis of the feature and influencing factors of anhedonia in schizophrenia

YU Ling-fang1, FANG Xin-yu2, CHEN Yan1, WANG Dan-dan1, WANG Ye-wei1, WU Ze-nan1, LIU Rui-mei1, ZHANG Chen1   

  1. 1. Department of Biochemistry and Pharmacology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China
  • Online:2020-09-28 Published:2020-11-04
  • Supported by:
    National Key Research and Development Program of China (2018YFC1314302); National Natural Science Foundation of China (81471358, 81771450); Western Medicine Guide Project of Shanghai Municipal Commission of Science and Technology (14411969000); Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20152530); Shanghai Municipal Commission of Health and Family Planning Foundation (201540029).

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摘要： 目的·探索精神分裂症快感缺失的临床特征及其相关的影响因素。方法·2018年12月至2019年12月期间纳入71名精神分裂症患者及50名健康志愿者，使用阳性和阴性症状量表（Positive and Negative Syndrome Scale，PANSS）评估患者的精神症状，使用时间性愉快体验量表（Temporal Experience of Pleasure Scale，TEPS）和重复性成套神经心理状态测验（Repeatable Battery for the Assessment of Neuropsychological Status，RBANS）分别评估被试的快感缺失和认知功能。结果·TEPS评估结果显示，精神分裂症的期待性快感和消费性快感得分均低于健康对照（P=0.000）。逐步线性回归结果显示PANSS中的阴性症状得分（B=-0.895，P=0.002）和RBANS五因子中的延迟记忆得分（B=0.265，P=0.001）与精神分裂症快感缺失有关。结论·精神分裂症患者存在期待性和消费性快感缺失，而精神分裂症阴性症状和认知功能均能影响快感缺失程度。

关键词: 精神分裂症, 快感缺失, 阴性症状, 延迟记忆

Abstract:

Objective · To explore the feature and influencing factors of anhedonia in schizophrenia. Methods · A total of 71 schizophrenia patients and 50 healthy controls were recruited during December 2018 and December 2019. Positive and Negative Syndrome Scale (PANSS) was used for assessing psychotic symptoms. Temporal Experience of Pleasure Scale (TEPS) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were applied to the evaluation of anhedonia and cognitive function respectively for each subject. Results · The evaluation result of TEPS showed both anticipatory and consummatory pleasure scores were lowered in patients with schizophrenia than those in healthy people (P=0.000). Stepwise linear regression analysis showed that negative subscale score of PANSS (B=-0.895, P=0.002) and delayed memory score of RBANS (B=0.265, P=0.001) were associated with anhedonia in schizophrenia. Conclusion · Patients with schizophrenia exhibit anticipatory and consummatory anhedonia, both of which are influenced by negative symptoms and delayed memory in schizophrenia.

Key words: schizophrenia, anhedonia, negative symptom, delayed memory

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