上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (09): 1283-1287.doi: 10.3969/j.issn.1674-8115.2020.09.019

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组蛋白变体macroH2A1调控肿瘤增殖的研究进展

张明达，冯海忠   

  1. 上海交通大学医学院附属仁济医院干细胞研究中心，上海200127
  • 出版日期:2020-09-28 发布日期:2020-11-04
  • 通讯作者: 冯海忠，电子信箱：fenghaizhong@sjtu.edu.cn。
  • 作者简介:张明达（1997—），男，博士生；电子信箱：zhangmd8@sjtu.edu.cn。
  • 基金资助:
    国家自然科学基金（81874078）；上海市教育委员会高峰高原学科建设计划（20161310）；上海市卫生和计划生育委员会优秀学科带头人人才培养计划（“新百人计划”）（2017BR021）。

Progress of histone variant macroH2A1 in tumor proliferation

ZHANG Ming-da, FENG Hai-zhong   

  1. Renji-Med X Clinical Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2020-09-28 Published:2020-11-04
  • Supported by:
    National Natural Science Foundation of China (81874078); Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20161310); New Hundred Talents Program (Outstanding Academic Leader) from Shanghai Municipal Commission of Health and Family Planning (2017BR021).

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摘要： 组蛋白变体不仅为染色质提供独特的功能，而且通过特殊的沉积和清除机制参与基因表达调控。macroH2A1是主要的组蛋白变体之一，早期发现其与女性X染色体失活和转录抑制有关，但目前研究发现其在特定的条件下可通过调控细胞衰老和代谢抑制肿瘤增殖。该文基于目前研究进展阐述macroH2A1调控基因表达的分子机制及其在肿瘤进展中的作用。

关键词: 组蛋白变体, macroH2A1, 肿瘤发生

Abstract:

Histone variants confer chromatin unique properties and also participate in the regulation of genetic expression through specific deposition and removal machineries. macroH2A1 is one of histone variants and has been found implicating in female X chromosome inactivation and transcriptional repression. However, recent marcoH2A1 has been reported to suppress tumor proliferation through regulating cellular senescence and metabolism under specific situations. The paper reviews the roles of macroH2A1 in tumorigenesis and the molecular mechanisms in regulating genetic expression based on current research progress.

Key words: histone variant, macroH2A1, tumorigenesis

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