上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (09): 1277-1282.doi: 10.3969/j.issn.1674-8115.2020.09.018

• 综述 • 上一篇    下一篇

妊娠期维生素A缺乏对子代神经发育影响的研究进展

张怡静1, 2，徐 健1, 2   

  1. 1. 上海交通大学医学院附属国际和平妇幼保健院儿童保健科，上海200030；2.上海交通大学医学院附属新华医院，教育部和上海市环境与儿童健康重点实验室，上海200092
  • 出版日期:2020-09-28 发布日期:2020-11-04
  • 通讯作者: 徐 健，电子信箱：sonia0616@sjtu.edu.cn。
  • 作者简介:张怡静（1995—），女，硕士生；电子信箱：sharemine@126.com。
  • 基金资助:
    上海市教育委员会高峰高原学科建设计划（20172016）；国家自然科学基金（81974486, 81673189）；国家重点研发计划（2016YFC1000203）。

Effect of maternal vitamin A deficiency during pregnancy on neurodevelopment of offspring

ZHANG Yi-jing1, 2, XU Jian1, 2   

  1. 1. Department of Children's Healthcare, International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. MOE-Shanghai Key Lab of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2020-09-28 Published:2020-11-04
  • Supported by:
    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20172016); National Natural Science Foundation of China (81974486, 81673189); National Key Research and Development Program of China (2016YFC1000203).

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摘要： 维生素A（vitamin A,VA）是一组具有全反式视黄醇生物活性的脂溶性维生素。孕妇是维生素A缺乏（vitamin A deficiency, VAD）的易感人群。VA除了参与视觉、免疫、皮肤表皮、生殖系统等的正常功能外，还广泛分布于脑组织中，有助于发育中的神经系统内神经祖细胞的模式生成和分化。孕期VA的活性代谢产物视黄酸对子代脑发育有非常重要的作用。该文回顾妊娠期VAD的既往文献，总结诱发妊娠期VAD的影响因素，根据相关的人群和动物研究结果总结妊娠期VAD对子代神经发育的影响；并从对子代胚层发育、脑结构发育、海马神经元的突触传递和生物钟的影响等多角度综述妊娠期VAD对子代神经发育影响的可能机制。

关键词: 妊娠期, 维生素A缺乏, 子代, 神经发育, 生物钟

Abstract:

Vitamin A (VA) is a fat-soluble vitamin with all-trans-retinoic biological activities. In addition to maintaining the normal functions of the eye, skin, immune, and reproductive systems, VA is also widely distributed in brain tissues, and important to the generation and differentiation of neural progenitor cells in the developing nervous system. Pregnant women are susceptible to vitamin A deficiency (VAD). Retinoic acid, the active form of VA, is very important to the brain development of offspring. This article reviews the literatures of maternal VAD during pregnancy, summarizing the risk factors of maternal VAD during pregnancy, and the research findings of the effects of maternal VAD during pregnancy on offspring neurodevelopment based on both human studies and animal experiments, and the possible underlying mechanisms by which maternal VAD affects the development of embryonic layers, brain structures, hippocampal synaptic transmission, and the biological clock in offspring.

Key words: pregnancy, vitamin A deficiency (VAD), offspring, neurodevelopment, biological clock

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