上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (09): 1288-1293.doi: 10.3969/j.issn.1674-8115.2020.09.020

• 综述 • 上一篇    下一篇

肿瘤相关成纤维细胞调控肿瘤免疫炎症微环境的研究进展

赵伟光，刘志宏   

  1. 上海交通大学附属第一人民医院泌尿外科，上海200080
  • 出版日期:2020-09-28 发布日期:2020-11-04
  • 通讯作者: 刘志宏，电子信箱：drzhihongliu@sjtu.edu.cn。
  • 作者简介:赵伟光（1997—），男，硕士生；电子信箱：zhaoweiguang97@163.com。
  • 基金资助:
    国家自然科学基金（81672515）；上海市教育委员会高峰高原学科建设计划（20172019）。

Advances in study of regulation of tumor immune inflammatory microenvironment by cancer-associated fibroblasts

ZHAO Wei-guang, LIU Zhi-hong   

  1. Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
  • Online:2020-09-28 Published:2020-11-04
  • Supported by:
    National Natural Science Foundation of China (81672515); Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20172019).

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摘要： 肿瘤相关成纤维细胞（cancer-associated fibroblasts，CAFs）是存在于肿瘤微环境中的一类重要细胞群。CAFs通过分泌多种可溶性分子重塑细胞外基质，促进肿瘤的生长及侵袭转移。目前认为CAFs在调控肿瘤免疫方面扮演着重要角色，因此越来越多的研究关注于CAFs重塑肿瘤免疫微环境的分子机制。该文从CAFs的分子标志物、CAFs与肿瘤细胞和免疫细胞之间的相互作用以及靶向CAFs的治疗进展等方面做一综述。

关键词: 肿瘤相关成纤维细胞, 肿瘤微环境, 肿瘤免疫

Abstract:

Cancer-associated fibroblasts (CAFs) are a major population that resides in the tumor microenvironment. Multiple soluble molecules secreted by CAFs remodel the extracellular matrix, thus promoting tumor growth, invasion and metastasis. It is now considered that CAFs play an important role in the regulation of tumor immunity, in which an increasing number of molecular mechanisms of tumor microenvironment remodeling are being discovered. This article reviews the molecular markers of CAFs, the crosstalk between CAFs and tumor cells or immune cells, as well as the progress on therapeutic targeting of CAFs.

Key words: cancer-associated fibroblasts (CAFs), tumor microenvironment, tumor immunity

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