上海交通大学学报(医学版) ›› 2021, Vol. 41 ›› Issue (4): 540-545.doi: 10.3969/j.issn.1674-8115.2021.04.021

• 综述 • 上一篇    下一篇

全氟化合物对性激素干扰作用的研究进展

汪子夏1(), 姚谦1, 田英1,2()   

  1. 1.上海交通大学公共卫生学院环境与健康系,上海 200025
    2.上海交通大学医学院附属新华医院环境与儿童健康重点实验室,上海 200092
  • 收稿日期:2020-03-03 出版日期:2021-04-28 发布日期:2021-05-14
  • 通讯作者: 田英 E-mail:Zi_xia@sjtu.edu.cn;tianmiejp@sjtu.edu.cn
  • 作者简介:汪子夏(1995—),女,硕士生,电子信箱:Zi_xia@sjtu.edu.cn
  • 基金资助:
    国家自然科学基金(81773387);上海交通大学“医工交叉”项目(YG2017MS84)

Advance in research of interference effect of perfluorinated compounds on sexhormones

Zi-xia WANG1(), Qian YAO1, Ying TIAN1,2()   

  1. 1.Department of Environmental Health, Shanghai Jiao Tong University School of Public Health, Shanghai 200025, China
    2.MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Received:2020-03-03 Online:2021-04-28 Published:2021-05-14
  • Contact: Ying TIAN E-mail:Zi_xia@sjtu.edu.cn;tianmiejp@sjtu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81773387);Interdisciplinary Program of Shanghai Jiao Tong University(YG2017MS84)

摘要:

全氟化合物(perfluorinated compounds,PFCs)是一类在环境和生物体内广泛存在的持久性有机污染物,已有研究表明其与肝脏毒性、免疫毒性、神经毒性等有关。近年来,越来越多的研究提示PFCs具有内分泌干扰效应,其生殖毒性备受关注,尤其是其对性激素合成分泌的影响。当性激素水平紊乱时,机体可能出现性分化发育异常、生殖障碍等表现。该文从动物毒理学研究及其机制、人群流行病学研究的角度,对PFCs与性激素水平的关系进行阐述,并对今后研究的方向进行讨论和展望。

关键词: 全氟化合物, 持久性有机污染物, 性激素

Abstract:

Perfluorinated compounds (PFCs) are a class of persistent organic pollutants that are widely distributed in the environment and biota. Studies have shown that PFCs have liver-toxicity, immune-toxicity and neuro-toxicity, etc. In recent years, due to an increasing number of studies suggesting that PFCs have endocrine disrupting effects, their reproductive toxicity has attracted much attention, especially their interference with the synthesis and secretion of sex hormone which may induce abnormalities in sexual differentiation and development, reproductive disorders, etc.This article reviews the relationship of PFCs with sex hormone levels and the potential mechanisms from animal toxicology experiments and epidemiological studies, thus providing the theoretical basis for PFCs research in the future.

Key words: perfluorinated compound, persistent organic pollutant, sex hormone

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