上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (2): 143-.

• 专题报道（儿科学研究） • 上一篇    下一篇

食物过敏原特异性IgG检测的临床意义

陈 嫕1, 陈同辛2, 朱亚忠2   

  1. 上海交通大学 医学院新华医院 1. 儿内科, 2. 上海市儿科医学研究所免疫/肿瘤研究室, 上海 200092
  • 出版日期:2010-02-25 发布日期:2010-02-25
  • 通讯作者: 陈同辛, 电子信箱: tongxinc@yahoo.com。
  • 作者简介:陈 嫕（1968—）, 女, 副主任医师, 硕士；电子信箱: shery_chen@126.com。

Clinical significance of food allergen-specific IgG detection

CHEN Yi1, CHEN Tong-xin2, ZHU Ya-zhong2   

  1. 1. Department of Pediatrics, 2. Department of Immunology/Oncology, Shanghai Institute for Pediatric Research, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China
  • Online:2010-02-25 Published:2010-02-25

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摘要：

目的 探讨14种食物过敏原特异性IgG检测的临床意义。方法 采用酶联免疫吸附法检测211例过敏性疾病患者血清中14种食物过敏原特异性IgG，并在不同年龄段、不同性别、不同疾病患者间比较各种食物IgG阳性率。结果 211例患者中，食物过敏原特异性IgG阳性者193例(91.4%)。14种食物中，鸡蛋的特异性IgG阳性率(73.9％)最高，其次为牛奶(70.6％)；未见鸡肉和猪肉的特异性IgG升高。0～12个月年龄组患者以牛奶为首要过敏原，其余年龄组均以鸡蛋为首要过敏原。牛奶特异性IgG阳性率在各年龄组间比较，差异有统计学意义 (P<0.01)。食物过敏原特异性IgG阳性率在男女患者间比较，差异无统计学意义(P>0.05)。湿疹患者食物过敏原特异性IgG阳性率（96.4%）最高，慢性腹泻患者阳性率（83.3%）最低；但各种疾病间比较，差异无统计学意义(P>0.05)；牛奶特异性IgG阳性率在各种疾病间比较，差异有统计学意义（P<0.01）；过敏性紫癜患者对12种过敏原（鸡肉和猪肉除外）均显示阳性反应。结论 食物不耐受是一种复杂的变态反应，血清食物过敏原特异性IgG的检测对过敏性疾病的病因诊断具有重要的指导意义。

关键词: 食物不耐受, 过敏原特异性IgG, 过敏性疾病

Abstract:

Objective To explore the clinical significance of detection of 14 kinds of food allergen-specific IgG. Methods Fourteen kinds of food allergen-specific IgG were detected by ELISA method in 211 patients with allergic diseases, and IgG positive rates of various foods were compared among patients with different sex, age and allergic diseases. Results Positive food allergen-specific IgG was detected in 193 (91.4%) patients. Among 14 kinds of foods, the positive rate of food allergen-specific IgG was the highest for eggs (73.9％), and milk came the second. However, no elevated food allergen-specific IgG was observed for chicken and meat. Milk was the most common sensitizers for 0-12 month-old patients, and egg was the first cause for the other age groups. There were significant differences in the positive rates of food allergen-specific IgG for milk among different age groups (P<0.01). There was no significant difference in the positive rate of food allergen-specific IgG between males and females (P>0.05). The positive rate of food allergen-specific IgG in patients with eczema was the highest (96.4%), and the lowest (83.3%) was found in those with chronic diarrhea, while there was no significant difference among different diseases (P>0.05). The positive rate of food allergen-specific IgG for milk differed significantly among different diseases (P<0.01). Positive food allergen-specific IgG was detected in 12 kinds of food (except for chicken and meat) for patients with allergic purpura. Conclusion Food intolerance is a complex allergy. The food allergen-specific IgG detection is of great importance as reference for etiologic diagnosis of allergic diseases.

Key words: food intolerance, allergen-specific IgG, allergic disease