上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (3): 256-.

• 专题报道（甲状腺癌核素治疗） • 上一篇    下一篇

分化型甲状腺癌131I治疗中多种核素显像的联合应用

邹仁健, 傅宏亮, 吴靖川, 李佳宁, 王 辉   

  1. 上海交通大学 医学院新华医院核医学科, 上海 200092
  • 出版日期:2010-03-25 发布日期:2010-03-24
  • 通讯作者: 王 辉, 电子信箱: wanghuishanghai@hotmail.com。
  • 作者简介:邹仁健(1967—), 男, 主管技师；电子信箱: tashanzhishi_2005@yahoo.com.cn。
  • 基金资助:

    上海市重点学科建设项目（S30203）

Clinical value of combination of multiple radionuclide imaging methods in 131I therapy for differentiated thyroid carcinoma

ZOU Ren-jian, FU Hong-liang, WU Jing-chuan, LI Jia-ning, WANG Hui   

  1. Department of Nuclear Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China
  • Online:2010-03-25 Published:2010-03-24
  • Supported by:

    Shanghai Leading Academic Discipline Project, S30203

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摘要：

目的 探讨提高分化型甲状腺癌(DTC)复发灶或转移灶检出率的最优化核素显像方法。方法 对89例DTC患者的临床资料进行回顾性分析。核素显像方法包括血清甲状腺球蛋白(Tg)检查结合放射性碘（131I）治疗剂量全身显像、99mTc-MIBI肿瘤显像和18F-FDG带符合线路的SPECT/CT全身显像，对三种核素显像的结果进行对比分析。结果 131I治疗剂量全身显像、99mTc-MIBI肿瘤显像和18F-FDG带符合线路的SPECT/CT全身显像的灵敏度分别为83.05%、79.66%和16.95%。结论 99mTc-MIBI肿瘤显像和18F-FDG带符合线路的SPECT/CT全身显像作为补充检查手段，可弥补血清Tg检查结合131I全身显像的局限性，对DTC患者复发灶或转移灶的检出、疗效评估及进一步治疗方案的制定具有重要意义。

关键词: 分化型甲状腺癌, 肿瘤显像, 99mTc-MIBI, 18F-FDG, 放射性碘

Abstract:

Objective To explore the optimal method of radionuclide imaging in detection of recurrence or metastasis of differentiated thyroid carcinoma (DTC). Methods The clinical data of 89 patients with DTC were retrospectively analysed. The results of radionuclide imaging methods of 131I whole body scan complemented with serum thyroglobulin(Tg) measurement, 99mTc-MIBI tumor scan and 18F-FDG coincidence SPECT/CT were compared and analysed. Results The sensitivities of 131I whole body scan, 99mTc-MIBI tumor scan and 18F-FDG coincidence SPECT/CT were 83.05%, 79.66% and 16.95%, respectively. Conclusion As complementary methods, 99mTc-MIBI tumor scan and 18F-FDG coincidence SPECT/CT can make up the limitation of 131I whole body scan simply complemented with serum Tg measurement, which may help to detect the recurrence and metastasis of DTC, evaluate the therapeutic effects and guide the therapy.

Key words: differentiated thyroid carcinoma, tumor scan, 99mTc-MIBI, 18F-FDG, radioactive iodine