上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (8): 1198-.doi: 10.3969/j.issn.1674-8115.2011.08.033

• 综述 • 上一篇    下一篇

吸入性麻醉剂在心肌缺血/再灌注损伤保护中的研究进展

宋 琳, 杭燕南   

  1. 上海交通大学 医学院附属仁济医院麻醉科, 上海 200001
  • 出版日期:2011-08-28 发布日期:2011-08-29
  • 通讯作者: 杭燕南, 电子信箱: prohynnc@hotmail.com。
  • 作者简介:宋 琳（1977—）, 女, 住院医师, 学士；电子信箱: songlin1977@yahoo.com.cn。

Research progress of protective effects of inhalation anesthetics in myocardial ischemia-reperfusion injury

SONG Lin, HANG Yan-nan   

  1. Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
  • Online:2011-08-28 Published:2011-08-29

PDF (PC)

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摘要：

如何预防和减轻心肌缺血/再灌注损伤（IR）一直是心血管研究领域中的热点问题之一。越来越多的基础研究证明吸入麻醉剂在缺血预适应和缺血后适应中都具有心肌保护作用；同时在进行体外循环的手术中也积累了一定数量的临床研究结果。目前认为，吸入麻醉剂是最有希望推广应用于临床实践的心肌保护措施，文章对这方面的研究进展作一综述。

关键词: 吸入性麻醉剂, 缺血/再灌注损伤, 预适应, 后适应

Abstract:

The prevention and amelioration of myocardial ischemia-reperfusion injury has long been a hotspot in the research of cardiology. Various laboratory studies have demonstrated that inhalation anesthetics play a protective role in the myocardial ischemic preconditioning and postconditioning. Meanwhile, a considerate number of clinical data have been accumulated from surgery with extracorporeal circulation. Inhalation anesthetics may be the most promising method of myocardial protection in clinical practice. The research progress of inhalation anesthetics in the mechanism of myocardial ischemia-reperfusion injury is reviewed in this paper.

Key words: inhalation anesthetics, ischemia-reperfusion injury, preconditioning, postconditioning